ArticleFrontiers in cardiovascular medicine2018
Can We Grow Valves Inside the Heart? Perspective on Material-based In Situ Heart Valve Tissue Engineering.
Article in Frontiers in cardiovascular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Cyclic stretch inhibits cell invasion in 3D scaffolds.bioRxiv : the preprint server for biology · 2026Article
- A custom preservation solution extends the ex vivo availability of living heart valves for transplantation.JTCVS open · 2025Article
- Full-Field Assessment of Geometry and Collagenous Architecture of Porcine Valve Leaflets via Laser Micrometry and Quantitative Polarized Light Imaging.Journal of biophotonics · 2025Article
- Influence of valve size on the hemodynamic performance of a tissue-engineered valved conduit in pulmonary position.Frontiers in bioengineering and biotechnology · 2025Article
- Towards a more objective and high-throughput spheroid invasion assay quantification method.Scientific reports · 2024Article
- Towards a More Objective and High-throughput Spheroid Invasion Assay Quantification Method.bioRxiv : the preprint server for biology · 2024Article
- A value hierarchy for inclusive design of heart valve implants in regenerative medicine.Regenerative medicine · 2024Article
- Evaluation of pliable bioresorbable, elastomeric aortic valve prostheses in sheep during 12 months post implantation.Communications biology · 2023Article
- Valvulogenesis of a living, innervated pulmonary root induced by an acellular scaffold.Communications biology · 2023Article
- Bio-Inspired Fiber Reinforcement for Aortic Valves: Scaffold Production Process and Characterization.Bioengineering (Basel, Switzerland) · 2023Article
- Lifelike Transformative Materials for Biohybrid Implants: Inspired by Nature, Driven by Technology.Advanced healthcare materials · 2023Article
- In Vitro Proof of Concept of a First-Generation Growth-Accommodating Heart Valved Conduit for Pediatric Use.Macromolecular bioscience · 2023Article
- Calcification in Pulmonary Heart Valve Tissue Engineering: A Systematic Review and Meta-Analysis of Large-Animal Studies.JACC. Basic to translational science · 2023Review
- Designing Biocompatible Tissue Engineered Heart Valves In Situ: JACC Review Topic of the Week.Journal of the American College of Cardiology · 2023Review
- Natural Polymers in Heart Valve Tissue Engineering: Strategies, Advances and Challenges.Biomedicines · 2022Review
- Tissue engineering: Relevance to neonatal congenital heart disease.Seminars in fetal & neonatal medicine · 2022Review
- Tissue response, macrophage phenotype, and intrinsic calcification induced by cardiovascular biomaterials: Can clinical regenerative potential be predicted in a rat subcutaneous implant model?Journal of biomedical materials research. Part A · 2022Article
- Immunological and functional features of decellularized xenogeneic heart valves after transplantation into GGTA1-KO pigs.Regenerative biomaterials · 2021Article
- Decellularized tissue-engineered heart valves calcification: what do animal and clinical studies tell us?Journal of materials science. Materials in medicine · 2020Review
- In Situ Remodeling Overrules Bioinspired Scaffold Architecture of Supramolecular Elastomeric Tissue-Engineered Heart Valves.JACC. Basic to translational science · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In situ heart valve tissue engineering using cell-free synthetic, biodegradable scaffolds is under development as a clinically attractive approach to create living valves right inside the heart of a patient. In this approach, a valve-shaped porous scaffold "implant" is rapidly populated by endogenous cells that initiate neo-tissue formation in pace with scaffold degradation. While this may constitute a cost-effective procedure, compatible with regulatory and clinical standards worldwide, the new technology heavily relies on the development of advanced biomaterials, the processing thereof into (minimally invasive deliverable) scaffolds, and the interaction of such materials with endogenous cells and neo-tissue under hemodynamic conditions. Despite the first positive preclinical results and the initiation of a small-scale clinical trial by commercial parties, in situ tissue formation is not well understood. In addition, it remains to be determined whether the resulting neo-tissue can grow with the body and preserves functional homeostasis throughout life. More important yet, it is still unknown if and how in situ tissue formation can be controlled under conditions of genetic or acquired disease. Here, we discuss the recent advances of material-based in situ heart valve tissue engineering and highlight the most critical issues that remain before clinical application can be expected. We argue that a combination of basic science - unveiling the mechanisms of the human body to respond to the implanted biomaterial under (patho)physiological conditions - and technological advancements - relating to the development of next generation materials and the prediction of in situ tissue growth and adaptation - is essential to take the next step towards a realistic and rewarding translation of in situ heart valve tissue engineering.
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