Evidence map›Paper›PMID 29896473›Full record

ArticleFrontiers in cell and developmental biology2018

Aging in a Relativistic Biological Space-Time.

Davide Maestrini, Daniel Abler, Vikram Adhikarla, Saro Armenian, Sergio Branciamore, Nadia Carlesso, Ya-Huei Kuo, Guido Marcucci, Prativa Sahoo, Russell C Rockne

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Davide MaestriniDivision of Mathematical Oncology, City of Hope, National Medical Center, Duarte, CA, United States.
Daniel AblerDivision of Mathematical Oncology, City of Hope, National Medical Center, Duarte, CA, United States.
Vikram AdhikarlaDivision of Mathematical Oncology, City of Hope, National Medical Center, Duarte, CA, United States.
Saro ArmenianDepartment of Pediatrics, City of Hope, National Medical Center, Duarte, CA, United States.
Sergio BranciamoreDivision of Mathematical Oncology, City of Hope, National Medical Center, Duarte, CA, United States.
Nadia CarlessoDepartment of Hematologic Malignancies Translational Science, City of Hope, National Medical Center, Duarte, CA, United States.
Ya-Huei KuoDepartment of Hematologic Malignancies Translational Science, City of Hope, National Medical Center, Duarte, CA, United States.
Guido MarcucciDepartment of Hematologic Malignancies Translational Science, City of Hope, National Medical Center, Duarte, CA, United States.
Prativa SahooDivision of Mathematical Oncology, City of Hope, National Medical Center, Duarte, CA, United States.
Russell C RockneDivision of Mathematical Oncology, City of Hope, National Medical Center, Duarte, CA, United States.

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI XIWEI WU · 1985 to 2026
$86.3M
Targeting MicroRNAs to Eradicate Leukemia Stem CellsR01CA205247 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI KUO, YA-HUEI, MARCUCCI, GUIDO · 2017 to 2025
$4.8M
Physiologic Regulation of Hematopoiesis by NotchR01DK097837 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI CARLESSO, NADIA · 2014 to 2017
$1.6M
HDAC8 Mediated Regulation of Acute Myeloid Leukemia Pathogenesis and MaintenanceR01CA178387 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI KUO, YA-HUEI · 2014 to 2018
$1.6M
NCI NIH HHS P30 CA033572NCI NIH HHS R01 CA178387NCI NIH HHS R01 CA205247NIDDK NIH HHS R01 DK097837
6 · The paper itself

Abstract

Here we present a theoretical and mathematical perspective on the process of aging. We extend the concepts of physical space and time to an abstract, mathematically-defined space, which we associate with a concept of "biological space-time" in which biological dynamics may be represented. We hypothesize that biological dynamics, represented as trajectories in biological space-time, may be used to model and study different rates of biological aging. As a consequence of this hypothesis, we show how dilation or contraction of time analogous to relativistic corrections of physical time resulting from accelerated or decelerated biological dynamics may be used to study precipitous or protracted aging. We show specific examples of how these principles may be used to model different rates of aging, with an emphasis on cancer in aging. We discuss how this theory may be tested or falsified, as well as novel concepts and implications of this theory that may improve our interpretation of biological aging.

Indexed as

agingbiological clocksbiological space-timemanifoldsspecial relativitytime-contraction

Identifiers

PMID29896473
PMCPMC5986934

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.