ArticleMetabolic engineering communications2018
Alleviation of reactive oxygen species enhances PUFA accumulation in
Article in Metabolic engineering communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 84 citations in OpenAlex.
- Strategies for enhancing the adaptive response to oxidative stress in microbial cell factories.World journal of microbiology & biotechnology · 2025Review
- Manipulating Intracellular Oxidative Conditions to Enhance Porphyrin Production inBioengineering (Basel, Switzerland) · 2025Article
- Development of Schizochytrium sp. strain HS01 with high-DHA and low-saturated fatty acids production by multi-pronged adaptive evolution.Biotechnology letters · 2023Article
- Alpha-Tocopherol Significantly Improved Squalene Production Yield ofAntioxidants (Basel, Switzerland) · 2023Article
- Nitrogen Starvation Enhances the Production of Saturated and Unsaturated Fatty Acids inMarine drugs · 2022Article
- Recent advances in genetic technology development of oleaginous yeasts.Applied microbiology and biotechnology · 2022Review
- THOR's Hammer: the Antibiotic Koreenceine Drives Gene Expression in a Model Microbial Community.mBio · 2022Article
- Metabolic Engineering Strategies for Improved Lipid Production and Cellular Physiological Responses in YeastJournal of fungi (Basel, Switzerland) · 2022Review
- Media Supplementation with Mannitol and Biotin Enhances Squalene Production ofMolecules (Basel, Switzerland) · 2022Article
- Production of microalgae with high lipid content and their potential as sources of nutraceuticals.Phytochemistry reviews : proceedings of the Phytochemical Society of Europe · 2022Review
- Propanol and 1, 3-propanediol enhance fatty acid accumulation synergistically inFrontiers in microbiology · 2022Article
- Strategic Development ofFrontiers in nutrition · 2022Article
- Chemical and Physical Culture Conditions Significantly Influence the Cell Mass and Docosahexaenoic Acid Content ofMarine drugs · 2021Article
- Exogenous Antioxidants Improve the Accumulation of Saturated and Polyunsaturated Fatty Acids inMarine drugs · 2021Article
- Method Development Progress in Genetic Engineering of Thraustochytrids.Marine drugs · 2021Review
- Development of an Efficient Gene Editing Tool inFrontiers in nutrition · 2021Article
- Different Classes of Phytohormones Act Synergistically to Enhance the Growth, Lipid and DHA Biosynthetic Capacity ofBiomolecules · 2020Article
- Stresses as First-Line Tools for Enhancing Lipid and Carotenoid Production in Microalgae.Frontiers in bioengineering and biotechnology · 2020Review
- Metabolic engineering to enhance biosynthesis of both docosahexaenoic acid and odd-chain fatty acids inBiotechnology for biofuels · 2019Article
- Flow-cytometry-based physiological characterisation and transcriptome analyses reveal a mechanism for reduced cell viability in yeast engineered for increased lipid content.Biotechnology for biofuels · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The unicellular heterotrophic thraustochytrids are attractive candidates for commercial polyunsaturated fatty acids (PUFA) production. However, the reactive oxygen species (ROS) generated in their aerobic fermentation process often limits their PUFA titer. Yet, the specific mechanisms of ROS involvement in the crosstalk between oxidative stress and intracellular lipid synthesis remain poorly described. Metabolic engineering to improve the PUFA yield in thraustochytrids without compromising growth is an important aspect of economic feasibility. To fill this gap, we overexpressed the antioxidative gene superoxide dismutase (SOD1) by integrating it into the genome of thraustochytrid
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.