Evidence map›Paper›PMID 29896366›Full record

ArticleChemical science2016

A structural view of synthetic cofactor integration into [FeFe]-hydrogenases.

J Esselborn, N Muraki, K Klein, V Engelbrecht, N Metzler-Nolte, U-P Apfel, E Hofmann, G Kurisu, T Happe

Abstract read
In one paragraph

Article in Chemical science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed.

  1. Electrochemical characterization of C. pasteurianum hydrogenase II and three site-directed variants: catalysis and inhibition.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026
    Article
  2. Synthesis of diiron subcluster [FeNature protocols · 2026
    Review
  3. Subunit fusion unlocks rapidChemical science · 2026
    Article
  4. Article
  5. [FeFe] hydrogenases with modified azadithiolate bridgeheads serve as unidirectional hydrogen oxidation catalysts.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026
    Article
  6. Hydrogen-Producing Catalysts Based on Ferredoxin Scaffolds.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  7. Magnetic interactions between metal sites in complex enzymes.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2025
    Review
  8. Review
  9. Article
  10. Distinct Valence States of the [4Fe4S] Cluster Revealed in the Hydrogenase CrHydA1.Angewandte Chemie (International ed. in English) · 2025
    Article
  11. Article
  12. Structural determinants of oxygen resistance and ZnProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. A personal account on 25 years of scientific literature on [FeFe]-hydrogenase.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2023
    Review
  18. Article
  19. Article
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

J EsselbornAG Photobiotechnologie , Fakultät für Biologie und Biotechnologie , Ruhr-Universität Bochum , Universitätsstraße 150 , 44801 Bochum , Germany . Email: thomas.happe@rub.de.ORCID 0000-0002-3499-8417
N MurakiLaboratory of Protein Crystallography , Institute for Protein Research , Osaka University , Suita , Osaka 565-0871 , Japan . Email: gkurisu@protein.Osaka-u.ac.
K KleinLehrstuhl für Anorganische Chemie I-Bioanorganische Chemie , Fakultät für Chemie und Biochemie , Ruhr-Universität Bochum , Universitätsstraße 150 , 44801 Bochum , Germany . Email: ulf.apfel@rub.de.
V EngelbrechtAG Photobiotechnologie , Fakultät für Biologie und Biotechnologie , Ruhr-Universität Bochum , Universitätsstraße 150 , 44801 Bochum , Germany . Email: thomas.happe@rub.de.
N Metzler-NolteLehrstuhl für Anorganische Chemie I-Bioanorganische Chemie , Fakultät für Chemie und Biochemie , Ruhr-Universität Bochum , Universitätsstraße 150 , 44801 Bochum , Germany . Email: ulf.apfel@rub.de.ORCID 0000-0001-8111-9959
U-P ApfelLehrstuhl für Anorganische Chemie I-Bioanorganische Chemie , Fakultät für Chemie und Biochemie , Ruhr-Universität Bochum , Universitätsstraße 150 , 44801 Bochum , Germany . Email: ulf.apfel@rub.de.
E HofmannAG Proteinkristallographie , Fakultät für Biologie und Biotechnologie , Ruhr-Universität Bochum , Universitätsstraße 150 , 44801 Bochum , Germany.ORCID 0000-0003-4874-372X
G KurisuLaboratory of Protein Crystallography , Institute for Protein Research , Osaka University , Suita , Osaka 565-0871 , Japan . Email: gkurisu@protein.Osaka-u.ac.
T HappeAG Photobiotechnologie , Fakultät für Biologie und Biotechnologie , Ruhr-Universität Bochum , Universitätsstraße 150 , 44801 Bochum , Germany . Email: thomas.happe@rub.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

[FeFe]-hydrogenases are nature's fastest catalysts for the evolution or oxidation of hydrogen. Numerous synthetic model complexes for the [2Fe] subcluster (2Fe

Identifiers

PMID29896366
PMCPMC5954619

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.