Evidence map›Paper›PMID 29896305›Full record

ArticleTheranostics2018

Ultrahigh-resolution optical coherence microscopy accurately classifies precancerous and cancerous human cervix free of labeling.

Xianxu Zeng, Xiaoan Zhang, Canyu Li, Xiaofang Wang, Jason Jerwick, Tao Xu, Yuan Ning, Yihong Wang, Linlin Zhang, Zhan Zhang and 2 more

Abstract read
In one paragraph

Article in Theranostics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xianxu ZengDepartment of Pathology, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Xiaoan ZhangDepartment of Imaging, the Third Affiliated Hospital, Zhengzhou University, Zhengzhou, 450052, China.
Canyu LiDepartment of Electrical and Computer Engineering, Lehigh University, Bethlehem PA 18015, USA.
Xiaofang WangDepartment of Electrical and Computer Engineering, Lehigh University, Bethlehem PA 18015, USA.
Jason JerwickDepartment of Electrical and Computer Engineering, Lehigh University, Bethlehem PA 18015, USA.
Tao XuDepartment of Electrical and Computer Engineering, Lehigh University, Bethlehem PA 18015, USA.
Yuan NingDepartment of Electrical and Computer Engineering, Lehigh University, Bethlehem PA 18015, USA.
Yihong WangDepartment of Pathology and Laboratory Medicine, Rhode Island Hospital/Warren Alpert Medical School of Brown University, Rhode Island 02912, USA.
Linlin ZhangDepartment of Clinical Laboratory, the Third Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China.
Zhan ZhangDepartment of Clinical Laboratory, the Third Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China.
Yutao MaState Key Laboratory of Software Engineering, Wuhan University, Wuhan 430072, China.
Chao ZhouDepartment of Electrical and Computer Engineering, Lehigh University, Bethlehem PA 18015, USA.

Funding

High throughput optical coherence tomography (OCT)-based imaging platform for label-free, non-invasive characterization of 3D tumor spheroids.R01EB025209 · NIBIB · WASHINGTON UNIVERSITY · PI ZHOU, CHAO · 2017 to 2021
$1.4M
Integrated Optical Coherence Tomography and Microscopy for Molecular-Targeted ImaR00EB010071 · NIBIB · LEHIGH UNIVERSITY · PI ZHOU, CHAO · 2012 to 2013
$479k
Integrated Optical Coherence Tomography and Microscopy for Molecular-Targeted ImaK99EB010071 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ZHOU, CHAO · 2011 to 2011
$90k
NIBIB NIH HHS K99 EB010071NIBIB NIH HHS R00 EB010071NIBIB NIH HHS R01 EB025209
6 · The paper itself

Abstract

Cervical cancer remains the fourth most common cause of cancer worldwide and the third leading cause of cancer deaths for women in developing countries. Traditional screening tools, such as human papillomavirus and Pap tests, cannot provide results in real-time and cannot localize suspicious regions. Colposcopy-directed biopsies are invasive in nature and only a few sites of the cervix may be chosen for investigation. A non-invasive, label-free and real-time imaging method with a resolution approaching that of histopathology is desirable for early detection of the disease.

Indexed as

AdultAgedAged, 80 and overBiopsyCervix UteriColposcopyFemaleHumansMass ScreeningMicroscopyMiddle AgedPrecancerous ConditionsSensitivity and SpecificityTomography, Optical CoherenceUterine Cervical NeoplasmsYoung Adultcervical canceroptical biopsyoptical coherence microscopy (OCM)optical coherence tomography (OCT)screening

Identifiers

PMID29896305
PMCPMC5996360

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.