Evidence map›Paper›PMID 29896159›Full record

ArticleFrontiers in endocrinology2018

Blockade of Endothelin-1 Receptor Type B Ameliorates Glucose Intolerance and Insulin Resistance in a Mouse Model of Obstructive Sleep Apnea.

Jan Polak, Naresh M Punjabi, Larissa A Shimoda

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Adipocyte-specific ETPhysiological reports · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Loss of endothelin type B receptor function improves insulin sensitivity in rats.Canadian journal of physiology and pharmacology · 2020
    Article
  11. Elevated plasma endothelin-1 is associated with reduced weight loss post vertical sleeve gastrectomy.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2019
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Jan PolakDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, United States.
Naresh M PunjabiDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, United States.
Larissa A ShimodaDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, United States.
Johns Hopkins University · USCharles University · CZ

Funding

Mechanisms Linking Sleep-Disordered Breathing and Cardiovascular DiseaseRC1HL099952 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI PUNJABI, NARESH M, SHIMODA, LARISSA A. · 2009 to 2010
$1000k
NHLBI NIH HHS F32 HL070578NHLBI NIH HHS RC1 HL099952
6 · The paper itself

Abstract

Obstructive sleep apnea (OSA) is associated with insulin resistance (IR) and glucose intolerance. Elevated endothelin-1 (ET-1) levels have been observed in OSA patients and in mice exposed to intermittent hypoxia (IH). We examined whether pharmacological blockade of type A and type B ET-1 receptors (ET

Indexed as

bosentandiabetesendothelinendothelin receptorobstructive sleep apnea

Identifiers

PMID29896159
PMCPMC5986958
OpenAlexW2800649608

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.