ReviewFrontiers in synaptic neuroscience2018
A Focus on Reward Prediction and the Lateral Habenula: Functional Alterations and the Behavioral Outcomes Induced by Drugs of Abuse.
Review in Frontiers in synaptic neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 37 citations in OpenAlex.
- Initial Drug Sensitivity and Vulnerability to Substance Use Disorders: A Review of Individual Influences.Biology · 2026Review
- DPP6 Loss Causes Age-Dependent Sleep Dysregulation and Depression-like Phenotypes Linked to Neurodegeneration.International journal of molecular sciences · 2026Article
- GPR139, an Ancient Receptor and an Emerging Target for Neuropsychiatric and Behavioral Disorders.Molecular neurobiology · 2025Review
- Effects of Repetitive Mild Traumatic Brain Injury on Corticotropin-Releasing Factor Modulation of Lateral Habenula Excitability and Motivated Behavior.Journal of neurotrauma · 2025Article
- A rare variant inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Disrupted functional connectome in a rodent model of autism during social isolation.Frontiers in neural circuits · 2025Article
- Effects of Repetitive Mild Traumatic Brain Injury on Corticotropin-Releasing Factor Modulation of Lateral Habenula Excitability and Motivated Behavior.bioRxiv : the preprint server for biology · 2024Article
- AKAP150-anchored PKA regulates synaptic transmission and plasticity, neuronal excitability and CRF neuromodulation in the mouse lateral habenula.Communications biology · 2024Article
- Mapping functional traces of opioid memories in the rat brain.Brain communications · 2024Article
- Developmental Changes in Habenular and Striatal Social Reinforcement Responsivity Across Adolescence Linked With Substance Use.Biological psychiatry · 2023Article
- Involvement of Lateral Habenula Dysfunction in Repetitive Mild Traumatic Brain Injury-Induced Motivational Deficits.Journal of neurotrauma · 2023Article
- Power signatures of habenular neuronal signals in patients with bipolar or unipolar depressive disorders correlate with their disease severity.Translational psychiatry · 2022Article
- Potentiation of glutamatergic synaptic transmission onto lateral habenula neurons following early life stress and intravenous morphine self-administration in rats.Addiction biology · 2022Article
- Lateral Habenula Beyond Avoidance: Roles in Stress, Memory, and Decision-Making With Implications for Psychiatric Disorders.Frontiers in systems neuroscience · 2022Article
- Roles of corticotropin-releasing factor signaling in the lateral habenula in anxiety-like and alcohol drinking behaviors in male rats.Neurobiology of stress · 2021Article
- Lateral Habenula 5-HTInternational journal of molecular sciences · 2021Article
- Role of Habenula in Social and Reproductive Behaviors in Fish: Comparison With Mammals.Frontiers in behavioral neuroscience · 2021Review
- Reward Processing and Circuit Dysregulation in Posttraumatic Stress Disorder.Frontiers in psychiatry · 2021Article
- The Emerging Role of LHb CaMKII in the Comorbidity of Depressive and Alcohol Use Disorders.International journal of molecular sciences · 2020Review
- Circuits and functions of the lateral habenula in health and in disease.Nature reviews. Neuroscience · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
The lateral habenula (LHb) regulates reward learning and controls the updating of reward-related information. Drugs of abuse have the capacity to hijack the cellular and neurocircuit mechanisms mediating reward learning, forming non-adaptable, compulsive behaviors geared toward obtaining illicit substances. Here, we discuss current findings demonstrating how drugs of abuse alter intrinsic and synaptic LHb neuronal function. Additionally, we discuss evidence for how drug-induced LHb alterations may affect the ability to predict reward, potentially facilitating an addiction-like state. Altogether, we combine
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.