ReviewFrontiers in neuroscience2018
Stress-Induced Functional Alterations in Amygdala: Implications for Neuropsychiatric Diseases.
Review in Frontiers in neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
60 citing papers in PubMed, 126 citations in OpenAlex.
- The Amygdala and Politics.Brain sciences · 2026Review
- Anxiety statistically mediates the association between stress and difficulty identifying feelings while depression shows no effect: a cross-sectional study in college students.BMC psychology · 2026Article
- Investigating the impact of stressful life events on neuroanatomy across adolescence.bioRxiv : the preprint server for biology · 2026Article
- Purinergic P2X7 receptor signaling in anxiety: Roles of stress-related neuroinflammatory mechanisms and therapeutic horizons.Purinergic signalling · 2026Review
- Associations between amygdala connectivity and experienced discrimination in children.bioRxiv : the preprint server for biology · 2026Article
- Neurobiophilia.Brain sciences · 2026Review
- Interoceptive NeuroEmpowerment Scale: a trauma-informed measure of adaptive state ownership.Frontiers in human neuroscience · 2026Article
- Sex-Specific Impact of Metabolic Syndrome on Brain Structures Vulnerable to Alzheimer's Disease: A Cross-Sectional Study in a Brazilian Cohort.Brain sciences · 2025Article
- Crocin alleviates neuronal arborization damage in the basolateral nucleus of the amygdala and dentate gyrus of the hippocampus in a stressed rat.IBRO neuroscience reports · 2025Article
- Chronic adolescent stress attenuates morphine-induced antinociception and central amygdala neuronal activation in adult Wistar rats.Physiology & behavior · 2025Article
- Botulinum Toxin: An Unconventional Tool for the Treatment of Depression?Brain sciences · 2025Review
- Burnout and the Brain-A Mechanistic Review of Magnetic Resonance Imaging (MRI) Studies.International journal of molecular sciences · 2025Review
- Traumatic brain injury graphing: A case study of Charles Whitman.Journal of forensic sciences · 2025Article
- Galactooligosaccharides Attenuate Behavioural, Haematological and Immunological Abnormalities and Influence Gut Microbiota in Rats with Amygdala Hyperactivation Induced by Electrical Stimulation.International journal of molecular sciences · 2025Article
- Associations between the neural-hematopoietic-inflammatory axis and DNA methylation of stress-related genes in human leukocytes: Data from the Washington, D.C. cardiovascular health and needs assessment.Brain, behavior, & immunity - health · 2025Article
- Genetic, Epigenetic, and Hormonal Regulation of Stress Phenotypes in Major Depressive Disorder: From Maladaptation to Resilience.Cellular and molecular neurobiology · 2025Review
- Early maladaptive schemas from child maltreatment in depression and psychotherapeutic remediation: a predictive coding framework.Frontiers in psychiatry · 2025Review
- Emotion Regulation Under Stress: A Social Processing and Memory Perspective.Current topics in behavioral neurosciences · 2025Review
- From trauma to depression: structural, synaptic, epigenetic, and molecular pathways linking early stress to lifelong vulnerability.Frontiers in psychiatry · 2025Review
- Gender differences in the associations of recreational walking with indoor and outdoor falls among older adults-the Healthy Aging and Neighborhood Study (HANS).AIMS public health · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The amygdala plays a major role in the processing of physiologic and behavioral responses to stress and is characterized by gamma-aminobutyric acid (GABA)-mediated high inhibitory tone under resting state. Human and animal studies showed that stress lead to a hyperactivity of amygdala, which was accompanied by the removal of inhibitory control. However, the contribution of hyperactivity of amygdala to stress-induced neuropsychiatric diseases, such as anxiety and mood disorders, is still dubious. In this review, we will summarize stress-induced various structural and functional alterations in amygdala, including the GABA receptors expression, GABAergic transmission and synaptic plasticity. It may provide new insight on the neuropathologic and neurophysiological mechanisms of neuropsychiatric diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.