ArticleInternational journal of health sciences
Streptozotocin-induced diabetes mellitus affects the NMDA receptors: Role of caffeine administration in enhancing learning, memory and locomotor deficits.
Article in International journal of health sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- Increased Apoptosis in Subcortical Regions of The Visual Pathway in Offspring Born to Diabetic Rats.Cell journal · 2023Article
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Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the deterioration of the brain functions by diabetes mellitus (DM) and the beneficial effect of caffeine. MATERIALS AND
methodsFirst, the component of N-methyl-D-aspartate receptors (NMDA) of the field excitatory postsynaptic potential (fEPSP) were recorded in streptozotocin (STZ)-induced DM and compared with control animals. Later, 40 mice were divided randomly into five groups (8 mice in each): (1) Normal control (Cont), (2) diabetic group (DM), (3) animals pretreated with i.p. caffeine before the induction of DM (Pre Caf), (4) acute caffeine-treated group (Ac Caf), and (5) chronic caffeine group (Ch Caf). Learning and memory were assessed in Morris-Water maze, and motor coordination was tested by rotarod.
resultsA significant reduction in the NMDA-component of the fEPSPs responses was recorded in the hippocampus of the diabetic animals. All the DM-groups demonstrated defects in learning and memory tasks; only the Ac Caf group could reverse the deteriorating effect of DM. This group showed a significantly lower latency values to reach their target (submerged platform) in the water maze in comparison to the DM, Pre Caf, and Ch Caf groups. Their performance was not significantly different from the control animals. Rotarod testing showed significant role of acute, but not chronic, caffeine administration in enhancing the motor skills.
conclusionSTZ -induced DM resulted into defects in memory tasks which are associated with a reduction in the hippocampal NMDA-receptor component of the fEPSP. Acute, but not chronic administration of caffeine could reverse the deteriorating effect of DM on learning and memory.
Indexed as
Identifiers
29896066PMC5969783W2943487856What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.