Evidence map›Paper›PMID 29895973›Full record

ArticleScientific reports2018

Transcriptomic and neurochemical analysis of the stellate ganglia in mice highlights sex differences.

R G Bayles, A Olivas, Q Denfeld, W R Woodward, S S Fei, L Gao, B A Habecker

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Electrophysiological comparison of left versus right stellate ganglia neurons.Journal of molecular and cellular cardiology plus · 2025
    Article
  3. Hypertension-induced heart failure disrupts cardiac sympathetic innervation.American journal of physiology. Heart and circulatory physiology · 2024
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

R G BaylesDepartment of Physiology and Pharmacology, Oregon Health & Science University, Portland, Oregon, 97239, USA.
A OlivasDepartment of Physiology and Pharmacology, Oregon Health & Science University, Portland, Oregon, 97239, USA.
Q DenfeldDepartment of Physiology and Pharmacology, Oregon Health & Science University, Portland, Oregon, 97239, USA.ORCID 0000-0001-7568-9568
W R WoodwardDepartment of Physiology and Pharmacology, Oregon Health & Science University, Portland, Oregon, 97239, USA.
S S FeiBiostatistics & Bioinformatics Core, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, 97006, USA.
L GaoBiostatistics & Bioinformatics Core, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, 97006, USA.
B A HabeckerDepartment of Physiology and Pharmacology, Oregon Health & Science University, Portland, Oregon, 97239, USA. habecker@ohsu.edu.ORCID 0000-0002-4658-8730
Oregon Health & Science University · USOregon National Primate Research Center · US

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
NIH HHS P51 OD011092
6 · The paper itself

Abstract

The stellate ganglia are the predominant source of sympathetic innervation to the heart. Remodeling of the nerves projecting to the heart has been observed in several cardiovascular diseases, however studies of adult stellate ganglia are limited. A profile of the baseline transcriptomic and neurochemical characteristics of the stellate ganglia in adult C57Bl6j mice, a common model for the study of cardiovascular diseases, may aid future investigations. We have generated a dataset of baseline measurements of mouse stellate ganglia using RNAseq, HPLC and mass spectrometry. Expression differences between male and female mice were identified. These differences included physiologically important genes for growth factors, receptors and ion channels. While the neurochemical profiles of male and female stellate ganglia were not different, minor differences in neurotransmitter content were identified in heart tissue.

Indexed as

Gene Expression ProfilingSex CharacteristicsAnimalsBrain ChemistryFemaleGene Expression RegulationMaleMiceStellate Ganglion

Identifiers

PMID29895973
PMCPMC5997635
OpenAlexW2805345346

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.