ArticleScientific reports2018
High genomic diversity of multi-drug resistant wastewater Escherichia coli.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- [Development and spread of antibiotic resistance in the environment due to increased anthropogenic input of antibiotic residues and resistant pathogens].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2026Review
- The Wastewater Resistome: A Shotgun Metagenomics Analysis of Urban Treatment Plants in Sicily.Antibiotics (Basel, Switzerland) · 2026Article
- Dynamics of genome evolution in the era of pangenome analysis.Cell genomics · 2026Review
- Ecological connectivity of genomic markers of antimicrobial resistance in Escherichia coli in Hong Kong.Nature communications · 2025Article
- Monitoring Antibiotic Resistance in Wastewater: Findings from Three Treatment Plants in Sicily, Italy.International journal of environmental research and public health · 2025Article
- Occurrence of "under-the-radar" antibiotic resistance in anthropogenically affected produce.The ISME journal · 2025Article
- Antibiotic Resistance Profile of EnterovirulentInternational journal of microbiology · 2025Article
- A Narrative Review of High Throughput Wastewater Sample Processing for Infectious Disease Surveillance: Challenges, Progress, and Future Opportunities.International journal of environmental research and public health · 2024Review
- Emergence of Carbapenemase Genes in Gram-Negative Bacteria Isolated from the Wastewater Treatment Plant in A Coruña, Spain.Antibiotics (Basel, Switzerland) · 2024Article
- A narrative review of wastewater surveillance: pathogens of concern, applications, detection methods, and challenges.Frontiers in public health · 2024Review
- Frequency of Fecal Carriage of ESBL Resistance Genes in Multidrug-ResistantInternational journal of microbiology · 2024Article
- Word-based GWAS harnesses the rich potential of genomic data forFrontiers in microbiology · 2023Article
- Combined Effect of Isolated Bacteriophage and Neem Extract on Isolated Multiple Drug-Resistant PathogenicEnvironmental health insights · 2023Article
- Antimicrobial Resistance Monitoring of Water Environments: A Framework for Standardized Methods and Quality Control.Environmental science & technology · 2022Review
- A genome-wide scan of wastewater E. coli for genes under positive selection: focusing on mechanisms of antibiotic resistance.Scientific reports · 2022Article
- NaturalizedFrontiers in microbiology · 2022Review
- Mutations inInternational journal of molecular sciences · 2021Article
- Niche and local geography shape the pangenome of wastewater- and livestock-associated Enterobacteriaceae.Science advances · 2021Article
- The level of antimicrobial resistance of sewage isolates is higher than that of river isolates in different Escherichia coli lineages.Scientific reports · 2020Article
- Effect of Urban Wastewater Discharge on the Abundance of Antibiotic Resistance Genes and Antibiotic-ResistantInternational journal of environmental research and public health · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wastewater treatment plants play an important role in the emergence of antibiotic resistance. They provide a hot spot for exchange of resistance within and between species. Here, we analyse and quantify the genomic diversity of the indicator Escherichia coli in a German wastewater treatment plant and we relate it to isolates' antibiotic resistance. Our results show a surprisingly large pan-genome, which mirrors how rich an environment a treatment plant is. We link the genomic analysis to a phenotypic resistance screen and pinpoint genomic hot spots, which correlate with a resistance phenotype. Besides well-known resistance genes, this forward genomics approach generates many novel genes, which correlated with resistance and which are partly completely unknown. A surprising overall finding of our analyses is that we do not see any difference in resistance and pan genome size between isolates taken from the inflow of the treatment plant and from the outflow. This means that while treatment plants reduce the amount of bacteria released into the environment, they do not reduce the potential for antibiotic resistance of these bacteria.
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