ArticleNature communications2018
Spatio-temporal relays control layer identity of direction-selective neuron subtypes in Drosophila.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Population morphology implies a common developmental blueprint for Drosophila motion detectors.PLoS computational biology · 2026Article
- Article
- Homotypic dendritic interactions constrain growth and receptor distribution in Drosophila T4 neurons without affecting orientation or function.Development (Cambridge, England) · 2026Article
- Temporal and Notch identity determine neuropil targeting depth and synapse location in the fly visual system.bioRxiv : the preprint server for biology · 2026Article
- Decoding neuronal diversity: Mechanisms governing neural cell fate in Drosophila.Current opinion in neurobiology · 2025Review
- Mechanistic insights into Wnt-β-catenin pathway activation and signal transduction.Nature reviews. Molecular cell biology · 2025Review
- Morphological and functional convergence of visual projection neurons from diverse neurogenic origins in Drosophila.Nature communications · 2025Article
- Spatial patterning controls neuron numbers in the Drosophila visual system.Developmental cell · 2024Article
- The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6.Nature communications · 2023Article
- Asymmetric requirement of Dpp/BMP morphogen dispersal in the Drosophila wing disc.Nature communications · 2021Article
- Pegasus, a small extracellular peptide enhancing short-range diffusion of Wingless.Nature communications · 2021Article
- Neural specification, targeting, and circuit formation during visual system assembly.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Integrated Patterning Programs DuringAnnual review of neuroscience · 2021Article
- Article
- Slit/Robo Signaling Regulates Multiple Stages of the Development of theFrontiers in cell and developmental biology · 2021Article
- Neuronal strategies for meeting the right partner during brain wiring.Current opinion in neurobiology · 2020Review
- A combinatorial code of transcription factors specifies subtypes of visual motion-sensing neurons inDevelopment (Cambridge, England) · 2020Article
- Article
- Neurogenesis From Embryo to Adult - Lessons From Flies and Mice.Frontiers in cell and developmental biology · 2020Review
- Gene regulatory networks during the development of the Drosophila visual system.Current topics in developmental biology · 2020Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Visual motion detection in sighted animals is essential to guide behavioral actions ensuring their survival. In Drosophila, motion direction is first detected by T4/T5 neurons. Their axons innervate one of the four lobula plate layers. How T4/T5 neurons with layer-specific representation of motion-direction preferences are specified during development is unknown. We show that diffusible Wingless (Wg) between adjacent neuroepithelia induces its own expression to form secondary signaling centers. These activate Decapentaplegic (Dpp) signaling in adjacent lateral tertiary neuroepithelial domains dedicated to producing layer 3/4-specific T4/T5 neurons. T4/T5 neurons derived from the core domain devoid of Dpp signaling adopt the default layer 1/2 fate. Dpp signaling induces the expression of the T-box transcription factor Optomotor-blind (Omb), serving as a relay to postmitotic neurons. Omb-mediated repression of Dachshund transforms layer 1/2- into layer 3/4-specific neurons. Hence, spatio-temporal relay mechanisms, bridging the distances between neuroepithelial domains and their postmitotic progeny, implement T4/T5 neuron-subtype identity.
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Registered trials
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