ArticleScientific reports2018
Opioid receptor signaling, analgesic and side effects induced by a computationally designed pH-dependent agonist.
Open access · goldAbstract read
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Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 63 citations in OpenAlex.
- Comparative analysis of continuous pericapsular nerve group block and supra-inguinal fascia iliaca compartment block for postoperative analgesia in total hip arthroplasty: a randomized controlled trial.Journal of orthopaedic surgery and research · 2025Trial
- A Systemically Administered Humanized Anti-Nav1.7 Antibody with Long-Lasting Analgesic Activity and Preserved Physiological Nociception.Pharmaceutics · 2026Article
- Emerging therapeutic approaches for treating abdominal pain.Journal of the Canadian Association of Gastroenterology · 2025Review
- To Compare Opioid Based versus Opioid-Free Anesthesia (Integrating with Erector Spinae Plane Block) in Laparoscopic Surgeries - A Prospective Study.Journal of pharmacy & bioallied sciences · 2025Article
- Discovery of Novel pH-Sensitive μ-Opioid Receptor Agonists as Potent Analgesics with Reduced Side Effects.ACS medicinal chemistry letters · 2025Article
- A pH-sensitive opioid does not exhibit analgesic tolerance in a mouse model of colonic inflammation.British journal of pharmacology · 2025Article
- Effects of pH on opioid receptor activation and implications for drug design.Biophysical journal · 2024Review
- Assessment of the antinociceptive, respiratory-depressant, and reinforcing effects of the low pKNeuropharmacology · 2024Article
- Novel multi-objective affinity approach allows to identify pH-specific μ-opioid receptor agonists.Journal of cheminformatics · 2023Article
- Modulation of G-protein activation, calcium currents and opioid receptor phosphorylation by the pH-dependent antinociceptive agonist NFEPP.Frontiers in molecular neuroscience · 2023Article
- Opioid-Induced Pronociceptive Signaling in the Gastrointestinal Tract Is Mediated by Delta-Opioid Receptor Signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Article
- Opioid-free anaesthesia for laparoscopic surgeries - A prospective non-randomised study in a tertiary care hospital.Indian journal of anaesthesia · 2022Article
- Opioid Receptors and Protonation-Coupled Binding of Opioid Drugs.International journal of molecular sciences · 2021Review
- Influence of G protein-biased agonists of μ-opioid receptor on addiction-related behaviors.Pharmacological reports : PR · 2021Review
- Recent Advances in Peripheral Opioid Receptor Therapeutics.Current pain and headache reports · 2021Review
- Targeting G protein-coupled receptors for the treatment of chronic pain in the digestive system.Gut · 2021Review
- How μ-opioid receptor recognizes fentanyl.Nature communications · 2021Article
- Recent advances in basic science methodology to evaluate opioid safety profiles and to understand opioid activities.Faculty reviews · 2021Review
- HowbioRxiv : the preprint server for biology · 2020Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Viola SpahnCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Anesthesiology and Intensive Care Medicine, Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany.ORCID 0000-0002-8086-8090
Giovanna Del VecchioCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Anesthesiology and Intensive Care Medicine, Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany.ORCID 0000-0002-2726-2014
Antonio Rodriguez-GaztelumendiCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Anesthesiology and Intensive Care Medicine, Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany.
Julia TempCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Anesthesiology and Intensive Care Medicine, Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany.ORCID 0000-0003-2523-798X
Dominika LabuzCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Anesthesiology and Intensive Care Medicine, Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany.
Michael KlonerCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Anesthesiology and Intensive Care Medicine, Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany.
Marco ReidelbachFreie Universität Berlin, Institute of Theoretical Physics, Arnimallee 14, 14195, Berlin, Germany.
Halina MachelskaCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Anesthesiology and Intensive Care Medicine, Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany.
Marcus WeberZuse Institute Berlin, Computational Molecular Design, Takustraße 7, 14195, Berlin, Germany.
Christoph SteinCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Anesthesiology and Intensive Care Medicine, Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany. Christoph.stein@charite.de.ORCID 0000-0001-5240-6836
Humboldt-Universität zu Berlin · DEFreie Universität Berlin · DEZuse Institute Berlin · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Novel pain killers without adverse effects are urgently needed. Opioids induce central and intestinal side effects such as respiratory depression, sedation, addiction, and constipation. We have recently shown that a newly designed agonist with a reduced acid dissociation constant (pK
Indexed as
AnalgesicsDrug DesignAnimalsDose-Response Relationship, DrugHydrogen-Ion ConcentrationMaleMolecular StructureMuramidaseNeuralgiaPeptide FragmentsPostoperative PainRatsRats, WistarReceptors, Opioid, muAnalgesicshen egg lysozyme peptide (115-129)MuramidasePeptide FragmentsReceptors, Opioid, mu
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.