Evidence map›Paper›PMID 29895870›Full record

ArticleNature communications2018

Spatially confined lignin nanospheres for biocatalytic ester synthesis in aqueous media.

Mika Henrikki Sipponen, Muhammad Farooq, Jari Koivisto, Alessandro Pellis, Jani Seitsonen, Monika Österberg

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 149 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Multifunctional lignin-based nanocomposites and nanohybrids.Green chemistry : an international journal and green chemistry resource : GC · 2021
    Review
  11. Article
  12. Article
  13. Review
  14. Lignin Nanoparticles and Their Nanocomposites.Nanomaterials (Basel, Switzerland) · 2021
    Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Lignin: Drug/Gene Delivery and Tissue Engineering Applications.International journal of nanomedicine · 2021
    Review
  20. Lignin for Bioeconomy: The Present and Future Role of Technical Lignin.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Mika Henrikki SipponenDepartment of Bioproducts and Biosystems, School of Chemical Engineering, Aalto University, PO BOX 16300, FI-00076 Aalto, Espoo, Finland. mika.sipponen@aalto.fi.ORCID http://orcid.org/0000-0001-7747-9310
Muhammad FarooqDepartment of Bioproducts and Biosystems, School of Chemical Engineering, Aalto University, PO BOX 16300, FI-00076 Aalto, Espoo, Finland.
Jari KoivistoDepartment of Chemistry and Materials Science, School of Chemical Engineering, Aalto University, PO BOX 16100, FI-00076 Aalto, Espoo, Finland.
Alessandro PellisDepartment of Chemistry, Green Chemistry Centre of Excellence, University of York, Heslington, York, YO10 5DD, UK.ORCID http://orcid.org/0000-0003-3711-3087
Jani SeitsonenNanomicroscopy Center, Department of Applied Physics, School of Science, Aalto University, PO BOX 11000, FI-00076 Aalto, Espoo, Finland.
Monika ÖsterbergDepartment of Bioproducts and Biosystems, School of Chemical Engineering, Aalto University, PO BOX 16300, FI-00076 Aalto, Espoo, Finland. monika.osterberg@aalto.fi.ORCID http://orcid.org/0000-0002-3558-9172
Aalto University · FIUniversity of York · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dehydration reactions proceed readily in water-filled biological cells. Development of biocatalysts that mimic such compartmentalized reactions has been cumbersome due to the lack of low-cost nanomaterials and associated technologies. Here we show that cationic lignin nanospheres function as activating anchors for hydrolases, and enable aqueous ester synthesis by forming spatially confined biocatalysts upon self-assembly and drying-driven aggregation in calcium alginate hydrogel. Spatially confined microbial cutinase and lipase retain 97% and 70% of their respective synthetic activities when the volume ratio of water to hexane increases from 1:1 to 9:1 in the reaction medium. The activity retention of industrially most frequently used acrylic resin-immobilized Candida antarctica lipase B is only 51% under similar test conditions. Overall, our findings enable fabrication of robust renewable biocatalysts for aqueous ester synthesis, and provide insight into the compartmentalization of diverse heterogeneous catalysts.

Indexed as

NanospheresAdsorptionAlginatesBiocatalysisBiocompatible MaterialsCandidaCatalysisColloidsEnzymes, ImmobilizedEstersFungal ProteinsHydrogelsHydrolysisLigninLipaseMagnetic Resonance SpectroscopyAlginatesBiocompatible MaterialsColloidsEnzymes, ImmobilizedEstersFungal ProteinsHydrogelsLigninLipaselipase B, Candida antarcticaWater

Identifiers

PMID29895870
PMCPMC5997711
OpenAlexW2806065742

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.