Evidence map›Paper›PMID 29895840›Full record

ArticlePediatric research2018

Altered metabolites in newborns with persistent pulmonary hypertension.

Martina A Steurer, Scott Oltman, Rebecca J Baer, Sky Feuer, Liang Liang, Randi A Paynter, Larry Rand, Kelli K Ryckman, Roberta L Keller, Laura L Jelliffe-Pawlowski

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Martina A SteurerDepartment of Pediatrics, University of California San Francisco, San Francisco, CA, USA. SteurerMullerM@peds.ucsf.edu.
Scott OltmanDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Rebecca J BaerCalifornia Preterm Birth Initiative, University of California San Francisco, San Francisco, CA, USA.
Sky FeuerCalifornia Preterm Birth Initiative, University of California San Francisco, San Francisco, CA, USA.
Liang LiangDepartment of Genetics, Stanford University, Palo Alto, CA, USA.
Randi A PaynterDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Larry RandDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.
Kelli K RyckmanDepartment of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USA.
Roberta L KellerDepartment of Pediatrics, University of California San Francisco, San Francisco, CA, USA.
Laura L Jelliffe-PawlowskiDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
University of California, San Francisco · USStanford University · USUniversity of California, San Diego · USUniversity of Iowa · US

Funding

Improving Prematurity-related Respiratory Outcomes at Vanderbilt (IMPROV)U01HL101456 · NHLBI · VANDERBILT UNIVERSITY · PI ASCHNER, JUDY LYNN · 2010 to 2014
$2.4M
Newborn Metabolic Screening for Prediction of Childhood Respiratory PhenotypesR21HD087864 · NICHD · UNIVERSITY OF IOWA · PI HARTERT, TINA V, RYCKMAN, KELLI K. · 2016 to 2017
$426k
NHLBI NIH HHS U01 HL101456NICHD NIH HHS R21 HD087864
6 · The paper itself

Abstract

backgroundThere is an emerging evidence that pulmonary hypertension is associated with amino acid, carnitine, and thyroid hormone aberrations. We aimed to characterize metabolic profiles measured by the newborn screen (NBS) in infants with persistent pulmonary hypertension of the newborn (PPHN)

methodsNested case-control study from population-based database. Cases were infants with ICD-9 code for PPHN receiving mechanical ventilation. Controls receiving mechanical ventilation were matched 2:1 for gestational age, sex, birth weight, parenteral nutrition administration, and age at NBS collection. Infants were divided into derivation and validation datasets. A multivariable logistic regression model was derived from candidate metabolites, and the area under the receiver operator characteristic curve (AUROC) was generated from the validation dataset.

resultsWe identified 1076 cases and 2152 controls. Four metabolites remained in the final model. Ornithine (OR 0.32, CI 0.26-0.41), tyrosine (OR 0.48, CI 0.40-0.58), and TSH 0.50 (0.45-0.55) were associated with decreased odds of PPHN; phenylalanine was associated with increased odds of PPHN (OR 4.74, CI 3.25-6.90). The AUROC was 0.772 (CI 0.737-0.807).

conclusionsIn a large, population-based dataset, infants with PPHN have distinct, early metabolic profiles. These data provide insight into the pathophysiology of PPHN, identifying potential therapeutic targets and novel biomarkers to assess the response.

Indexed as

Area Under CurveBirth WeightCase-Control StudiesFemaleGestational AgeHumansInfant, NewbornLogistic ModelsMaleMultivariate AnalysisNeonatal ScreeningOrnithinePersistent Fetal Circulation SyndromePhenylalanineRespiration, ArtificialThyrotropinOrnithinePhenylalanineThyrotropinTyrosine

Identifiers

PMID29895840
PMCPMC7691760
OpenAlexW2807993472

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.