ArticlePediatric research2018
Predictive value of early EEG for seizures in neonates with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia.
Article in Pediatric research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- Seizures after initiation of rewarming in cooled infants with hypoxic ischaemic encephalopathy.Pediatric research · 2024Trial
- Efficacy of different treatment times of mild cerebral hypothermia on oxidative factors and neuroprotective effects in neonatal patients with moderate/severe hypoxic-ischemic encephalopathy.The Journal of international medical research · 2020Trial
- AES ILAE North America Symposium: Guiding Evidence-Based Epilepsy Management.Epilepsy currents · 2026Article
- Short-horizon neonatal seizure prediction using EEG-based deep learning.PLOS digital health · 2025Article
- Observational
- Machine learning for forecasting initial seizure onset in neonatal hypoxic-ischemic encephalopathy.Epilepsia · 2025Article
- Quantitative EEG in the neonatal intensive care unit: Current application and future promise.Annals of the Child Neurology Society · 2023Review
- Review of Noninvasive Neuromonitoring Modalities in Children II: EEG, qEEG.Neurocritical care · 2023Review
- Neuromonitoring in neonatal critical care part I: neonatal encephalopathy and neonates with possible seizures.Pediatric research · 2023Review
- Machine learning for the early prediction of infants with electrographic seizures in neonatal hypoxic-ischemic encephalopathy.Epilepsia · 2023Article
- Analgesia and sedation strategies in neonates undergoing whole-body therapeutic hypothermia: A scoping review.PloS one · 2023Article
- Neonatal seizures: stepping outside the comfort zone.Clinical and experimental pediatrics · 2022Article
- Bedside and laboratory neuromonitoring in neonatal encephalopathy.Seminars in fetal & neonatal medicine · 2021Review
- Neonatal Seizures Revisited.Children (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo assess the prognostic significance of an early normal/mildly abnormal conventional EEG (cEEG) on seizure risk in neonates undergoing therapeutic hypothermia.
methodsWe reviewed the video-EEG recordings from a large cohort of neonates treated with therapeutic hypothermia for hypoxic-ischemic encephalopathy from 2008 to 2017 in a single tertiary center. Continuous video-EEG was started as soon as possible (median 8.2 h) and continued throughout hypothermia and rewarming. We studied those neonates with a normal/mildly abnormal EEG during the first 24 h of monitoring.
resultsA total of 331 neonates were treated with hypothermia and 323 had cEEG recordings available for review; 99 were excluded because of a moderately/severely abnormal cEEG background and/or seizure during the first 24 h of recording, and an additional eight because of early rewarming. The remaining 216 had a normal/mildly abnormal cEEG in the first 24 h. None of these patients subsequently developed seizures.
conclusionA normal/mildly abnormal cEEG during the first 24 h indicates a very low risk of subsequent seizures. This suggests that cEEG monitoring can be safely discontinued after 24 h if it has remained normal or excessively discontinuous and no seizures are detected, limiting the need for this resource-intensive and expensive tool.
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