Evidence map›Paper›PMID 29895756›Full record

ArticleMolecules (Basel, Switzerland)2018

(-)-Shikimic Acid as a Chiral Building Block for the Synthesis of New Cytotoxic 6-Aza-Analogues of Angucyclinones.

Natalia Quiñones, Santiago Hernández, Luis Espinoza Catalán, Joan Villena, Ivan Brito, Alan R Cabrera, Cristian O Salas, Mauricio A Cuellar

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Natalia QuiñonesCentro de Investigación Farmacopea Chilena, Escuela de Química y Farmacia, Facultad de Farmacia, Universidad de Valparaíso, Av. Gran Bretaña N° 1093, Valparaíso 2340000, Chile. natalia.quinones@uv.cl.
Santiago HernándezCentro de Investigación Farmacopea Chilena, Escuela de Química y Farmacia, Facultad de Farmacia, Universidad de Valparaíso, Av. Gran Bretaña N° 1093, Valparaíso 2340000, Chile. santiago.hernandez@postgrado.uv.cl.
Luis Espinoza CatalánDepartamento de Química, Universidad Técnica Federico Santa María, Av. España N° 1680, Valparaíso 2340000, Chile. luis.espinozac@usm.cl.ORCID 0000-0002-4054-7487
Joan VillenaCentro de Investigaciones Biomédicas, Escuela de Medicina, Universidad de Valparaíso, Av. Hontaneda N° 2664, Valparaíso 2340000, Chile. juan.villena@uv.cl.
Ivan BritoDepartamento de Química, Facultad de Ciencias Básicas, Universidad de Antofagasta, Av. Angamos 601, Antofagasta 1240000, Chile. ivan.brito@uantof.cl.
Alan R CabreraDepartamento de Química Orgánica, Facultad de Química, Pontificia Universidad Católica de Chile, Vicuña Mackenna N° 4860, Santiago 6094411, Chile. arcabrer@uc.cl.
Cristian O SalasDepartamento de Química Orgánica, Facultad de Química, Pontificia Universidad Católica de Chile, Vicuña Mackenna N° 4860, Santiago 6094411, Chile. cosalas@uc.cl.
Mauricio A CuellarCentro de Investigación Farmacopea Chilena, Escuela de Química y Farmacia, Facultad de Farmacia, Universidad de Valparaíso, Av. Gran Bretaña N° 1093, Valparaíso 2340000, Chile. mauricio.cuellar@uv.cl.
University of Valparaíso · CLFederico Santa María Technical University · CLPontificia Universidad Católica de Chile · CLUniversidad de Antofagasta · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe the syntheses of nine new angucyclinone 6-aza-analogues, achieved through a hetero Diels-Alder reaction between the shikimic acid derivative-azadiene

Indexed as

AnthraquinonesAntineoplastic AgentsCell Line, TumorCell ProliferationCell SurvivalCycloaddition ReactionDrug Screening Assays, AntitumorHT29 CellsHumansMCF-7 CellsMolecular StructureShikimic AcidStructure-Activity RelationshipangucyclinoneAnthraquinonesAntineoplastic AgentsShikimic Acidangucyclinone derivativescancer cell linescytotoxicityhetero-Diels-Alder(-)-Shikimic acid

Identifiers

PMID29895756
PMCPMC6099682
OpenAlexW2808498142

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.