Evidence map›Paper›PMID 29895712›Full record

ArticleEMBO reports2018

Dual role of USP30 in controlling basal pexophagy and mitophagy.

Elena Marcassa, Andreas Kallinos, Jane Jardine, Emma V Rusilowicz-Jones, Aitor Martinez, Sandra Kuehl, Markus Islinger, Michael J Clague, Sylvie Urbé

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMBO reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 3 pooled it
11.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 3 syntheses or guidelines pooled it, 160 citations in OpenAlex.

  1. Pooled it
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  3. Guideline
  4. Regulation and roles of mammalian mitophagy.Nature reviews. Molecular cell biology · 2026
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33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Elena MarcassaCellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
Andreas KallinosCellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
Jane JardineCellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
Emma V Rusilowicz-JonesCellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
Aitor MartinezCellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
Sandra KuehlInstitute of Neuroanatomy, Centre for Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Markus IslingerInstitute of Neuroanatomy, Centre for Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Michael J ClagueCellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK clague@liv.ac.uk urbe@liv.ac.uk.ORCID 0000-0003-3355-9479
Sylvie UrbéCellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK clague@liv.ac.uk urbe@liv.ac.uk.ORCID 0000-0003-4735-9814
University of Liverpool · GBHeidelberg University · DE

Funding

Medical Research Council MR/N00941X/1
6 · The paper itself

Abstract

USP30 is an integral protein of the outer mitochondrial membrane that counteracts PINK1 and Parkin-dependent mitophagy following acute mitochondrial depolarisation. Here, we use two distinct mitophagy reporter systems to reveal tonic suppression by USP30, of a PINK1-dependent component of basal mitophagy in cells lacking detectable Parkin. We propose that USP30 acts upstream of PINK1 through modulation of PINK1-substrate availability and thereby determines the potential for mitophagy initiation. We further show that a fraction of endogenous USP30 is independently targeted to peroxisomes where it regulates basal pexophagy in a PINK1- and Parkin-independent manner. Thus, we reveal a critical role of USP30 in the clearance of the two major sources of ROS in mammalian cells and in the regulation of both a PINK1-dependent and a PINK1-independent selective autophagy pathway.

Indexed as

AutophagyCell LineHumansMitochondriaMitochondrial ProteinsMitophagyPeroxisomesProtein KinasesPTEN-Induced Putative KinaseReactive Oxygen SpeciesThiolester HydrolasesUbiquitin-Protein LigasesMitochondrial Proteinsparkin proteinProtein KinasesPTEN-Induced Putative KinaseReactive Oxygen SpeciesThiolester HydrolasesUbiquitin-Protein LigasesUsp30 protein, humanmitochondriamitophagyperoxisomesPINK1ubiquitinUSP30

Identifiers

PMID29895712
PMCPMC6030704
OpenAlexW2807910244

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.