Evidence map›Paper›PMID 29895700›Full record

ArticleJournal of lipid research2018

Acute depletion of diacylglycerol from the

Gary Hong Chun Chung, Marie-Charlotte Domart, Christopher Peddie, Judith Mantell, Kieran Mclaverty, Angela Arabiotorre, Lorna Hodgson, Richard D Byrne, Paul Verkade, Kenton Arkill and 2 more

Abstract read
In one paragraph

Article in Journal of lipid research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Gary Hong Chun ChungCell Biophysics Laboratory, Ikerbasque Basque Foundation for Science, Research Centre for Experimental Marine Biology and Biotechnology (PiE) and Biofísika Institute (UPV/EHU, CSIC), University of the Basque Country, Barrio Sarriena s/n 48940, Leioa, Spain.
Marie-Charlotte DomartElectron Microscopy Science Technology Platform, Francis Crick Institute, London, United Kingdom.
Christopher PeddieElectron Microscopy Science Technology Platform, Francis Crick Institute, London, United Kingdom.
Judith MantellSchool of Biochemistry, Faculty of Biomedical Sciences, University of Bristol, Bristol, United Kingdom.
Kieran MclavertyCell Biophysics Laboratory, Ikerbasque Basque Foundation for Science, Research Centre for Experimental Marine Biology and Biotechnology (PiE) and Biofísika Institute (UPV/EHU, CSIC), University of the Basque Country, Barrio Sarriena s/n 48940, Leioa, Spain.
Angela ArabiotorreCell Biophysics Laboratory, Ikerbasque Basque Foundation for Science, Research Centre for Experimental Marine Biology and Biotechnology (PiE) and Biofísika Institute (UPV/EHU, CSIC), University of the Basque Country, Barrio Sarriena s/n 48940, Leioa, Spain.
Lorna HodgsonSchool of Biochemistry, Faculty of Biomedical Sciences, University of Bristol, Bristol, United Kingdom.
Richard D ByrneCell Biophysics Laboratory, Ikerbasque Basque Foundation for Science, Research Centre for Experimental Marine Biology and Biotechnology (PiE) and Biofísika Institute (UPV/EHU, CSIC), University of the Basque Country, Barrio Sarriena s/n 48940, Leioa, Spain.
Paul VerkadeSchool of Biochemistry, Faculty of Biomedical Sciences, University of Bristol, Bristol, United Kingdom.
Kenton ArkillCell Biophysics Laboratory, Ikerbasque Basque Foundation for Science, Research Centre for Experimental Marine Biology and Biotechnology (PiE) and Biofísika Institute (UPV/EHU, CSIC), University of the Basque Country, Barrio Sarriena s/n 48940, Leioa, Spain Kenton.Arkill@nottingham.ac.uk lucy.collinson@crick.ac.uk banafshe.larijani@ikerbasque.org.
Lucy M CollinsonElectron Microscopy Science Technology Platform, Francis Crick Institute, London, United Kingdom Kenton.Arkill@nottingham.ac.uk lucy.collinson@crick.ac.uk banafshe.larijani@ikerbasque.org.
Banafshé LarijaniCell Biophysics Laboratory, Ikerbasque Basque Foundation for Science, Research Centre for Experimental Marine Biology and Biotechnology (PiE) and Biofísika Institute (UPV/EHU, CSIC), University of the Basque Country, Barrio Sarriena s/n 48940, Leioa, Spain Kenton.Arkill@nottingham.ac.uk lucy.collinson@crick.ac.uk banafshe.larijani@ikerbasque.org.ORCID 0000-0003-4735-1169

Funding

British Heart Foundation PG/15/37/31438Medical Research Council MR/K01580X/1Medical Research Council MR/P003214/1Wellcome Trust FC001999
6 · The paper itself

Abstract

Dysregulation of nuclear envelope (NE) assembly results in various cancers; for example, renal and some lung carcinomas ensue due to NE malformation. The NE is a dynamic membrane compartment and its completion during mitosis is a highly regulated process, but the detailed mechanism still remains incompletely understood. Previous studies have found that isolated diacylglycerol (DAG)-containing vesicles are essential for completing the fusion of the NE in nonsomatic cells. We investigated the impact of DAG depletion from the

Indexed as

MitosisDiglyceridesGolgi ApparatusHeLa CellsHumansNuclear EnvelopeDiglyceridescorrelative light electron microscopymembrane curvatureserial block face scanning electron microscopy

Identifiers

PMID29895700
PMCPMC6071775

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.