Evidence map›Paper›PMID 29895688›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Ancient genomes from North Africa evidence prehistoric migrations to the Maghreb from both the Levant and Europe.

Rosa Fregel, Fernando L Méndez, Youssef Bokbot, Dimas Martín-Socas, María D Camalich-Massieu, Jonathan Santana, Jacob Morales, María C Ávila-Arcos, Peter A Underhill, Beth Shapiro and 9 more

Erratum issuedAbstract readComparative StudyHistorical Article
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 88 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Estimating human mobility in Holocene Western Eurasia with large-scale ancient genomic data.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Pooled it
  2. Article
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  6. Sudan's complex genetic admixture history drives adaptation to malaria in Sudanese Copts.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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  8. Global patterns of natural selection inferred using ancient DNA.bioRxiv : the preprint server for biology · 2026
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28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Rosa FregelDepartment of Genetics, School of Medicine, Stanford University, Stanford, CA 94305; rfregel@ull.edu.es.
Fernando L MéndezDepartment of Genetics, School of Medicine, Stanford University, Stanford, CA 94305.
Youssef BokbotInstitut National des Sciences de l'Archéologie et du Patrimoine, 6828 Rabat, Morocco.
Dimas Martín-SocasDepartmento de Prehistoria, Universidad de La Laguna, 38320 San Cristóbal de La Laguna, Spain.
María D Camalich-MassieuDepartmento de Prehistoria, Universidad de La Laguna, 38320 San Cristóbal de La Laguna, Spain.
Jonathan SantanaDepartment of Archaeology, Durham University, DH1 3LE Durham, United Kingdom.
Jacob MoralesDepartamento de Ciencias Históricas, Universidad de Las Palmas de Gran Canaria, 35003 Las Palmas de Gran Canaria, Spain.
María C Ávila-ArcosDepartment of Genetics, School of Medicine, Stanford University, Stanford, CA 94305.
Peter A UnderhillDepartment of Genetics, School of Medicine, Stanford University, Stanford, CA 94305.
Beth ShapiroDepartment of Ecology and Evolutionary Biology, University of California, Santa Cruz, CA 95064.ORCID 0000-0002-2733-7776
Genevieve WojcikDepartment of Genetics, School of Medicine, Stanford University, Stanford, CA 94305.
Morten RasmussenDepartment of Genetics, School of Medicine, Stanford University, Stanford, CA 94305.
André E R SoaresDepartment of Ecology and Evolutionary Biology, University of California, Santa Cruz, CA 95064.ORCID 0000-0002-7768-2199
Joshua KappDepartment of Ecology and Evolutionary Biology, University of California, Santa Cruz, CA 95064.
Alexandra SockellDepartment of Genetics, School of Medicine, Stanford University, Stanford, CA 94305.
Francisco J Rodríguez-SantosInstituto Internacional de Investigaciones Prehistóricas de Cantabria, 39005 Cantabria, Spain.
Abdeslam MikdadInstitut National des Sciences de l'Archéologie et du Patrimoine, 6828 Rabat, Morocco.
Aioze Trujillo-MederosDepartmento de Prehistoria, Universidad de La Laguna, 38320 San Cristóbal de La Laguna, Spain.
Carlos D BustamanteDepartment of Genetics, School of Medicine, Stanford University, Stanford, CA 94305.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The extent to which prehistoric migrations of farmers influenced the genetic pool of western North Africans remains unclear. Archaeological evidence suggests that the Neolithization process may have happened through the adoption of innovations by local Epipaleolithic communities or by demic diffusion from the Eastern Mediterranean shores or Iberia. Here, we present an analysis of individuals' genome sequences from Early and Late Neolithic sites in Morocco and from Early Neolithic individuals from southern Iberia. We show that Early Neolithic Moroccans (∼5,000 BCE) are similar to Later Stone Age individuals from the same region and possess an endemic element retained in present-day Maghrebi populations, confirming a long-term genetic continuity in the region. This scenario is consistent with Early Neolithic traditions in North Africa deriving from Epipaleolithic communities that adopted certain agricultural techniques from neighboring populations. Among Eurasian ancient populations, Early Neolithic Moroccans are distantly related to Levantine Natufian hunter-gatherers (∼9,000 BCE) and Pre-Pottery Neolithic farmers (∼6,500 BCE). Late Neolithic (∼3,000 BCE) Moroccans, in contrast, share an Iberian component, supporting theories of trans-Gibraltar gene flow and indicating that Neolithization of North Africa involved both the movement of ideas and people. Lastly, the southern Iberian Early Neolithic samples share the same genetic composition as the Cardial Mediterranean Neolithic culture that reached Iberia ∼5,500 BCE. The cultural and genetic similarities between Iberian and North African Neolithic traditions further reinforce the model of an Iberian migration into the Maghreb.

Indexed as

Genome, HumanAfrica, NorthernAgricultureChromosomes, Human, YDNA, MitochondrialEthnicityEuropeGene FlowGene LibraryGenetics, PopulationHistory, AncientHuman MigrationHumansMiddle EastMoroccoSequence Analysis, DNADNA, Mitochondrialancient DNANeolithic transitionNorth Africapaleogenomics

Identifiers

PMID29895688
PMCPMC6042094

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.