Evidence map›Paper›PMID 29895625›Full record

Trial reportBlood advances2018

Differential antibacterial control by neutrophil subsets.

Pieter H C Leliefeld, Janesh Pillay, Nienke Vrisekoop, Marjolein Heeres, Tamar Tak, Matthijs Kox, Suzan H M Rooijakkers, Taco W Kuijpers, Peter Pickkers, Luke P H Leenen and 1 more

Abstract readClinical TrialMulticenter Study
In one paragraph

Trial report in Blood advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Recent Advances in Camel Immunology.Frontiers in immunology · 2020
    Pooled it
  2. Trial
  3. Injury to the thorax is a dominant contributor to post-traumatic neutrophil mediated inflammatory response.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026
    Article
  4. Review
  5. Ly6GeLife · 2026
    Article
  6. Review
  7. Article
  8. Review
  9. Immature CD10Frontiers in immunology · 2026
    Article
  10. Article
  11. Association of CD16Journal of inflammation research · 2026
    Article
  12. Review
  13. Article
  14. Defining the early systemic neutrophil signature after severe trauma: decreased CD10/CD16 levels on admission precedes metabolic dysregulation.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025
    Article
  15. Article
  16. Exploratory Study of CD10Scandinavian journal of immunology · 2025
    Article
  17. Exploring the role of systemic inflammation in guiding clinical decision making for geriatric patients with a hip fracture.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025
    Article
  18. Article
  19. Article
  20. Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Pieter H C LeliefeldDepartment of Surgery.ORCID 0000-0002-9264-0704
Janesh PillayLaboratory of Translational Immunology, and.ORCID 0000-0001-8037-6638
Nienke VrisekoopLaboratory of Translational Immunology, and.ORCID 0000-0002-7361-1780
Marjolein HeeresDepartment of Surgery.
Tamar TakLaboratory of Translational Immunology, and.ORCID 0000-0002-5959-7927
Matthijs KoxDepartment of Intensive Care, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.ORCID 0000-0001-6537-6971
Suzan H M RooijakkersDepartment of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands; and.ORCID 0000-0003-4102-0377
Taco W KuijpersEmma Children's Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Peter PickkersDepartment of Intensive Care, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.ORCID 0000-0002-1104-4303
Luke P H LeenenDepartment of Surgery.ORCID 0000-0001-8385-1801
Leo KoendermanLaboratory of Translational Immunology, and.ORCID 0000-0002-5636-6453

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neutrophils comprise a heterogeneous population of cells essential for bacterial eradication, and defects in neutrophil function are associated with increased susceptibility to infection. In this study, neutrophils from healthy controls were shown to prevent bacterial proliferation for at least 48 hours when cocultured with methicillin-resistant

Indexed as

PhagocytosisAcute DiseaseAdolescentChildChild, PreschoolFemaleGPI-Linked ProteinsHumansInflammationL-SelectinMaleMethicillin-Resistant Staphylococcus aureusNeutrophilsPhagosomesReactive Oxygen SpeciesReceptors, IgGFCGR3B protein, humanGPI-Linked ProteinsL-SelectinReactive Oxygen SpeciesReceptors, IgG

Identifiers

PMID29895625
PMCPMC5998927

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.