Evidence map›Paper›PMID 29895592›Full record

ArticleMolecular pharmacology2018

Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992.

Sujay V Kharade, Haruto Kurata, Aaron M Bender, Anna L Blobaum, Eric E Figueroa, Amanda Duran, Meghan Kramer, Emily Days, Paige Vinson, Daniel Flores and 6 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
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  4. KiScience · 2025
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  9. The involvement of KTranslational psychiatry · 2024
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Inward rectifier potassium (Kir) channels in the retina: living our vision.American journal of physiology. Cell physiology · 2022
    Review
  18. Kir5.1 channels: potential role in epilepsy and seizure disorders.American journal of physiology. Cell physiology · 2022
    Review
  19. Inwardly rectifying KAmerican journal of physiology. Cell physiology · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Sujay V KharadeDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee (S.V.K., M.K., J.S.D.); Center for Neuroscience Drug Discovery and the Vanderbilt Specialized Chemistry Center for Accelerated Probe Development (H.K., A.M.B., A.L.B., C.W.L., C.R.H.), Departments of Pharmacology (H.K., A.M.B., E.E.F., J.M., C.D.W., C.W.L., J.S.D.) and Chemistry (A.D., J.M., C.D.W., C.W.L.), High-Throughput Screening Center (E.D., P.V.), and Institute of Chemical Biology (C.D.W., C.W.L., J.S.D.), Vanderbilt University, Nashville, Tennessee; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York (D.F., L.M.S.); and Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska (C.R.H.).
Haruto KurataDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee (S.V.K., M.K., J.S.D.); Center for Neuroscience Drug Discovery and the Vanderbilt Specialized Chemistry Center for Accelerated Probe Development (H.K., A.M.B., A.L.B., C.W.L., C.R.H.), Departments of Pharmacology (H.K., A.M.B., E.E.F., J.M., C.D.W., C.W.L., J.S.D.) and Chemistry (A.D., J.M., C.D.W., C.W.L.), High-Throughput Screening Center (E.D., P.V.), and Institute of Chemical Biology (C.D.W., C.W.L., J.S.D.), Vanderbilt University, Nashville, Tennessee; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York (D.F., L.M.S.); and Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska (C.R.H.).
Aaron M BenderDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee (S.V.K., M.K., J.S.D.); Center for Neuroscience Drug Discovery and the Vanderbilt Specialized Chemistry Center for Accelerated Probe Development (H.K., A.M.B., A.L.B., C.W.L., C.R.H.), Departments of Pharmacology (H.K., A.M.B., E.E.F., J.M., C.D.W., C.W.L., J.S.D.) and Chemistry (A.D., J.M., C.D.W., C.W.L.), High-Throughput Screening Center (E.D., P.V.), and Institute of Chemical Biology (C.D.W., C.W.L., J.S.D.), Vanderbilt University, Nashville, Tennessee; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York (D.F., L.M.S.); and Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska (C.R.H.).
Anna L BlobaumDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee (S.V.K., M.K., J.S.D.); Center for Neuroscience Drug Discovery and the Vanderbilt Specialized Chemistry Center for Accelerated Probe Development (H.K., A.M.B., A.L.B., C.W.L., C.R.H.), Departments of Pharmacology (H.K., A.M.B., E.E.F., J.M., C.D.W., C.W.L., J.S.D.) and Chemistry (A.D., J.M., C.D.W., C.W.L.), High-Throughput Screening Center (E.D., P.V.), and Institute of Chemical Biology (C.D.W., C.W.L., J.S.D.), Vanderbilt University, Nashville, Tennessee; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York (D.F., L.M.S.); and Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska (C.R.H.).
Eric E FigueroaDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee (S.V.K., M.K., J.S.D.); Center for Neuroscience Drug Discovery and the Vanderbilt Specialized Chemistry Center for Accelerated Probe Development (H.K., A.M.B., A.L.B., C.W.L., C.R.H.), Departments of Pharmacology (H.K., A.M.B., E.E.F., J.M., C.D.W., C.W.L., J.S.D.) and Chemistry (A.D., J.M., C.D.W., C.W.L.), High-Throughput Screening Center (E.D., P.V.), and Institute of Chemical Biology (C.D.W., C.W.L., J.S.D.), Vanderbilt University, Nashville, Tennessee; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York (D.F., L.M.S.); and Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska (C.R.H.).
Amanda DuranDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee (S.V.K., M.K., J.S.D.); Center for Neuroscience Drug Discovery and the Vanderbilt Specialized Chemistry Center for Accelerated Probe Development (H.K., A.M.B., A.L.B., C.W.L., C.R.H.), Departments of Pharmacology (H.K., A.M.B., E.E.F., J.M., C.D.W., C.W.L., J.S.D.) and Chemistry (A.D., J.M., C.D.W., C.W.L.), High-Throughput Screening Center (E.D., P.V.), and Institute of Chemical Biology (C.D.W., C.W.L., J.S.D.), Vanderbilt University, Nashville, Tennessee; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York (D.F., L.M.S.); and Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska (C.R.H.).
Meghan KramerDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee (S.V.K., M.K., J.S.D.); Center for Neuroscience Drug Discovery and the Vanderbilt Specialized Chemistry Center for Accelerated Probe Development (H.K., A.M.B., A.L.B., C.W.L., C.R.H.), Departments of Pharmacology (H.K., A.M.B., E.E.F., J.M., C.D.W., C.W.L., J.S.D.) and Chemistry (A.D., J.M., C.D.W., C.W.L.), High-Throughput Screening Center (E.D., P.V.), and Institute of Chemical Biology (C.D.W., C.W.L., J.S.D.), Vanderbilt University, Nashville, Tennessee; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York (D.F., L.M.S.); and Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska (C.R.H.).
Emily DaysDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee (S.V.K., M.K., J.S.D.); Center for Neuroscience Drug Discovery and the Vanderbilt Specialized Chemistry Center for Accelerated Probe Development (H.K., A.M.B., A.L.B., C.W.L., C.R.H.), Departments of Pharmacology (H.K., A.M.B., E.E.F., J.M., C.D.W., C.W.L., J.S.D.) and Chemistry (A.D., J.M., C.D.W., C.W.L.), High-Throughput Screening Center (E.D., P.V.), and Institute of Chemical Biology (C.D.W., C.W.L., J.S.D.), Vanderbilt University, Nashville, Tennessee; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York (D.F., L.M.S.); and Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska (C.R.H.).
Paige VinsonDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee (S.V.K., M.K., J.S.D.); Center for Neuroscience Drug Discovery and the Vanderbilt Specialized Chemistry Center for Accelerated Probe Development (H.K., A.M.B., A.L.B., C.W.L., C.R.H.), Departments of Pharmacology (H.K., A.M.B., E.E.F., J.M., C.D.W., C.W.L., J.S.D.) and Chemistry (A.D., J.M., C.D.W., C.W.L.), High-Throughput Screening Center (E.D., P.V.), and Institute of Chemical Biology (C.D.W., C.W.L., J.S.D.), Vanderbilt University, Nashville, Tennessee; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York (D.F., L.M.S.); and Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska (C.R.H.).
Daniel FloresDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee (S.V.K., M.K., J.S.D.); Center for Neuroscience Drug Discovery and the Vanderbilt Specialized Chemistry Center for Accelerated Probe Development (H.K., A.M.B., A.L.B., C.W.L., C.R.H.), Departments of Pharmacology (H.K., A.M.B., E.E.F., J.M., C.D.W., C.W.L., J.S.D.) and Chemistry (A.D., J.M., C.D.W., C.W.L.), High-Throughput Screening Center (E.D., P.V.), and Institute of Chemical Biology (C.D.W., C.W.L., J.S.D.), Vanderbilt University, Nashville, Tennessee; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York (D.F., L.M.S.); and Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska (C.R.H.).
Lisa M SatlinDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee (S.V.K., M.K., J.S.D.); Center for Neuroscience Drug Discovery and the Vanderbilt Specialized Chemistry Center for Accelerated Probe Development (H.K., A.M.B., A.L.B., C.W.L., C.R.H.), Departments of Pharmacology (H.K., A.M.B., E.E.F., J.M., C.D.W., C.W.L., J.S.D.) and Chemistry (A.D., J.M., C.D.W., C.W.L.), High-Throughput Screening Center (E.D., P.V.), and Institute of Chemical Biology (C.D.W., C.W.L., J.S.D.), Vanderbilt University, Nashville, Tennessee; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York (D.F., L.M.S.); and Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska (C.R.H.).
Jens MeilerDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee (S.V.K., M.K., J.S.D.); Center for Neuroscience Drug Discovery and the Vanderbilt Specialized Chemistry Center for Accelerated Probe Development (H.K., A.M.B., A.L.B., C.W.L., C.R.H.), Departments of Pharmacology (H.K., A.M.B., E.E.F., J.M., C.D.W., C.W.L., J.S.D.) and Chemistry (A.D., J.M., C.D.W., C.W.L.), High-Throughput Screening Center (E.D., P.V.), and Institute of Chemical Biology (C.D.W., C.W.L., J.S.D.), Vanderbilt University, Nashville, Tennessee; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York (D.F., L.M.S.); and Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska (C.R.H.).
C David WeaverDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee (S.V.K., M.K., J.S.D.); Center for Neuroscience Drug Discovery and the Vanderbilt Specialized Chemistry Center for Accelerated Probe Development (H.K., A.M.B., A.L.B., C.W.L., C.R.H.), Departments of Pharmacology (H.K., A.M.B., E.E.F., J.M., C.D.W., C.W.L., J.S.D.) and Chemistry (A.D., J.M., C.D.W., C.W.L.), High-Throughput Screening Center (E.D., P.V.), and Institute of Chemical Biology (C.D.W., C.W.L., J.S.D.), Vanderbilt University, Nashville, Tennessee; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York (D.F., L.M.S.); and Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska (C.R.H.).
Craig W LindsleyDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee (S.V.K., M.K., J.S.D.); Center for Neuroscience Drug Discovery and the Vanderbilt Specialized Chemistry Center for Accelerated Probe Development (H.K., A.M.B., A.L.B., C.W.L., C.R.H.), Departments of Pharmacology (H.K., A.M.B., E.E.F., J.M., C.D.W., C.W.L., J.S.D.) and Chemistry (A.D., J.M., C.D.W., C.W.L.), High-Throughput Screening Center (E.D., P.V.), and Institute of Chemical Biology (C.D.W., C.W.L., J.S.D.), Vanderbilt University, Nashville, Tennessee; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York (D.F., L.M.S.); and Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska (C.R.H.).
Corey R HopkinsDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee (S.V.K., M.K., J.S.D.); Center for Neuroscience Drug Discovery and the Vanderbilt Specialized Chemistry Center for Accelerated Probe Development (H.K., A.M.B., A.L.B., C.W.L., C.R.H.), Departments of Pharmacology (H.K., A.M.B., E.E.F., J.M., C.D.W., C.W.L., J.S.D.) and Chemistry (A.D., J.M., C.D.W., C.W.L.), High-Throughput Screening Center (E.D., P.V.), and Institute of Chemical Biology (C.D.W., C.W.L., J.S.D.), Vanderbilt University, Nashville, Tennessee; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York (D.F., L.M.S.); and Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska (C.R.H.).
Jerod S DentonDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee (S.V.K., M.K., J.S.D.); Center for Neuroscience Drug Discovery and the Vanderbilt Specialized Chemistry Center for Accelerated Probe Development (H.K., A.M.B., A.L.B., C.W.L., C.R.H.), Departments of Pharmacology (H.K., A.M.B., E.E.F., J.M., C.D.W., C.W.L., J.S.D.) and Chemistry (A.D., J.M., C.D.W., C.W.L.), High-Throughput Screening Center (E.D., P.V.), and Institute of Chemical Biology (C.D.W., C.W.L., J.S.D.), Vanderbilt University, Nashville, Tennessee; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York (D.F., L.M.S.); and Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska (C.R.H.) jerod.s.denton@vanderbilt.edu corey.hopkins@unmc.edu.
Icahn School of Medicine at Mount Sinai · USVanderbilt University Medical Center · USUniversity of Nebraska Medical Center · USVanderbilt University · US

Funding

Decrypting Variants of Uncertain Significance in Long-QT SyndromeR01HL122010 · NHLBI · VANDERBILT UNIVERSITY · PI GEORGE, ALFRED L., SANDERS, CHARLES R · 2014 to 2025
$15.5M
Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2008 to 2022
$13.4M
TRAINING IN PHARMACOLOGICAL SCIENCEST32GM007628 · NIGMS · VANDERBILT UNIVERSITY · PI BARNETT, JOEY VICTOR, KAVALALI, EGE T · 1985 to 2022
$11.2M
Vanderbilt/Meharry Initiative for Minority Student DvptR25GM062459 · NIGMS · VANDERBILT UNIVERSITY · PI VELEZ EDWARDS, DIGNA R · 2002 to 2020
$10.4M
Regulation of K and H secretion by intercalated cellsR01DK038470 · NIDDK · YESHIVA UNIVERSITY · PI HUGHEY, REBECCA P, KLEYMAN, THOMAS R · 1994 to 2022
$7.7M
Membrane Protein Structure Elucidation from sparse NMR data (KAMP)R01GM080403 · NIGMS · VANDERBILT UNIVERSITY · PI MEILER, JENS · 2007 to 2019
$3.0M
Molecular pharmacology and physiology of kidney potassium transportR01DK082884 · NIDDK · VANDERBILT UNIVERSITY · PI DENTON, JEROD S. · 2010 to 2014
$1.3M
Fluorescent and Luminescent Kinetic Imaging Plate ReaderS10OD021734 · OD · VANDERBILT UNIVERSITY · PI LINDSLEY, CRAIG · 2016 to 2016
$671k
GPU-Accelerated Parallel Computer for Drug Discovery ApplicationsS10OD020154 · OD · VANDERBILT UNIVERSITY · PI SMITH, JARROD ANSON · 2015 to 2015
$225k
Chemical probes of the astroglial potassium channel Kir4.1R21NS073097 · NINDS · VANDERBILT UNIVERSITY · PI DENTON, JEROD S. · 2010 to 2012
$180k
NHLBI NIH HHS R01 HL122010NIDDK NIH HHS P30 DK079307NIDDK NIH HHS R01 DK038470NIDDK NIH HHS R01 DK082884NIGMS NIH HHS R01 GM080403NIGMS NIH HHS R25 GM062459NIGMS NIH HHS T32 GM007628NIH HHS S10 OD021734NINDS NIH HHS R21 NS073097
6 · The paper itself

Abstract

The inward rectifier potassium (Kir) channel Kir4.1 (

Indexed as

AnimalsBinding SitesDiureticsElectrolytesHEK293 CellsHumansKcnj10 ChannelMaleModels, MolecularMolecular Docking SimulationMolecular StructureMutagenesis, Site-DirectedPotassium Channels, Inwardly RectifyingRatsSmall Molecule LibrariesSubstrate SpecificityDiureticsElectrolytesKcnj10 ChannelPotassium Channels, Inwardly RectifyingSmall Molecule Libraries

Identifiers

PMID29895592
PMCPMC6041953
OpenAlexW2808434449

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.