ArticleGenetics2018
Introgression of a Block of Genome Under Infinitesimal Selection.
Article in Genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Haplotype structure: an overlooked key factor shaping the genomic selection response.Genetics · 2026Article
- On the Causes of Correlated Genomic Ancestry Across Contrasting Hybridization Histories in a Monkeyflower Species Pair.Molecular ecology · 2026Article
- Limited Selection on Neanderthal DNA in 30,780 Recently Admixed Genomes with African-like Ancestry.Molecular biology and evolution · 2026Article
- On the causes of correlated genomic ancestry across contrasting hybridization histories in a monkeyflower species pair.bioRxiv : the preprint server for biology · 2026Article
- A theory of oligogenic adaptation of a quantitative trait.Genetics · 2023Article
- The infinitesimal model with dominance.Genetics · 2023Article
- The fitness of an introgressing haplotype changes over the course of divergence and depends on its size and genomic location.PLoS biology · 2023Article
- How predictable is adaptation from standing genetic variation? Experimental evolution inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Interspecific introgression of MHC genes in Triturus newts: Evidence from multiple contact zones.Molecular ecology · 2023Article
- Hybrid fitness effects modify fixation probabilities of introgressed alleles.G3 (Bethesda, Md.) · 2022Article
- Widespread introgression across a phylogeny of 155 Drosophila genomes.Current biology : CB · 2022Article
- A dense linkage map for a large repetitive genome: discovery of the sex-determining region in hybridizing fire-bellied toads (Bombina bombina and Bombina variegata).G3 (Bethesda, Md.) · 2021Article
- Highly Parallel Genomic Selection Response in Replicated Drosophila melanogaster Populations with Reduced Genetic Variation.Genome biology and evolution · 2021Article
- Anchoring alien chromosome segment substitutions bearing gene(s) for resistance to mustard aphid in Brassica juncea-B. fruticulosa introgression lines and their possible disruption through gamma irradiation.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- The genetic architecture of temperature adaptation is shaped by population ancestry and not by selection regime.Genome biology · 2021Article
- An Experimental Test of Adaptive Introgression in Locally Adapted Populations of Splash Pool Copepods.Molecular biology and evolution · 2021Article
- The rates of introgression and barriers to genetic exchange between hybridizing species: sex chromosomes vs autosomes.Genetics · 2021Article
- Polygenic adaptation: a unifying framework to understand positive selection.Nature reviews. Genetics · 2020Review
- On the Distribution of Tract Lengths During Adaptive Introgression.G3 (Bethesda, Md.) · 2020Article
- Tadpoles of hybridising fire-bellied toads (B. bombina and B. variegata) differ in their susceptibility to predation.PloS one · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adaptive introgression is common in nature and can be driven by selection acting on multiple, linked genes. We explore the effects of polygenic selection on introgression under the infinitesimal model with linkage. This model assumes that the introgressing block has an effectively infinite number of loci, each with an infinitesimal effect on the trait under selection. The block is assumed to introgress under directional selection within a native population that is genetically homogeneous. We use individual-based simulations and a branching process framework to compute various statistics of the introgressing block, and explore how these depend on parameters such as the map length and initial trait value associated with the introgressing block, the genetic variability along the block, and the strength of selection. Our results show that the introgression dynamics of a block under infinitesimal selection are qualitatively different from the dynamics of neutral introgression. We also find that, in the long run, surviving descendant blocks are likely to have intermediate lengths, and clarify how their length is shaped by the interplay between linkage and infinitesimal selection. Our results suggest that it may be difficult to distinguish the long-term introgression of a block of genome with a single, strongly selected, locus from the introgression of a block with multiple, tightly linked and weakly selected loci.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.