Evidence map›Paper›PMID 29895532›Full record

ArticleHypertension (Dallas, Tex. : 1979)2018

Antihypertensive Treatment Fails to Control Blood Pressure During Exercise.

Benjamin Chant, Majda Bakali, Thomas Hinton, Amy E Burchell, Angus K Nightingale, Julian F R Paton, Emma C Hart

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 69 citations in OpenAlex.

  1. Trial
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  5. Sex-specific association between obesity and sympathetic nerve activity in HFpEF.American journal of physiology. Heart and circulatory physiology · 2026
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  11. Longitudinal changes in cardiovascular and sympathetic neural responses to static handgrip exercise throughout pregnancy.American journal of physiology. Regulatory, integrative and comparative physiology · 2025
    Article
  12. Article
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  15. Maintained sympathetic reactivity but blunted pressor response to static handgrip exercise in heart failure with preserved ejection fraction.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Benjamin ChantFrom the Bristol Heart Institute (BHI) CardioNomics Research Group, Clinical Research and Imaging Centre, School of Physiology, Pharmacology, Neuroscience (B.C., M.B., T.H., J.F.R.P., E.C.H.).
Majda BakaliFrom the Bristol Heart Institute (BHI) CardioNomics Research Group, Clinical Research and Imaging Centre, School of Physiology, Pharmacology, Neuroscience (B.C., M.B., T.H., J.F.R.P., E.C.H.).
Thomas HintonFrom the Bristol Heart Institute (BHI) CardioNomics Research Group, Clinical Research and Imaging Centre, School of Physiology, Pharmacology, Neuroscience (B.C., M.B., T.H., J.F.R.P., E.C.H.).
Amy E BurchellDepartment of Cardiology, Bristol Heart Institute, University Hospitals Bristol National Health Service (NHS) Foundation Trust, United Kingdom (A.E.B., A.K.N.).
Angus K NightingaleBristol Medical School, Translational Health Sciences (A.K.N.), University of Bristol, United Kingdom.
Julian F R PatonFrom the Bristol Heart Institute (BHI) CardioNomics Research Group, Clinical Research and Imaging Centre, School of Physiology, Pharmacology, Neuroscience (B.C., M.B., T.H., J.F.R.P., E.C.H.).
Emma C HartFrom the Bristol Heart Institute (BHI) CardioNomics Research Group, Clinical Research and Imaging Centre, School of Physiology, Pharmacology, Neuroscience (B.C., M.B., T.H., J.F.R.P., E.C.H.) emma.hart@bristol.ac.uk.
NIHR Bristol Cardiovascular Biomedical Research Unit · GBUniversity Hospitals Bristol NHS Foundation Trust · GBUniversity of Auckland · NZUniversity of Bristol · GB

Funding

British Heart Foundation FS/11/1/28400British Heart Foundation RG/12/6/29670
6 · The paper itself

Abstract

An exaggerated blood pressure (BP) response to maximal exercise is an independent risk factor for cardiovascular events and mortality. It is unclear whether treating BP to guideline recommended levels could normalize the rise in BP during exercise, which is mediated by the metaboreflex. We aimed to assess the BP response to incremental exercise testing and metaboreflex activation in treated-controlled hypertension (n=16), treated-uncontrolled hypertension (n=16), and untreated hypertension (n=11) and 16 control participants with normal BP (n=16). All groups were matched for age and body mass index. BP was measured during an incremental Vo

Indexed as

AgedAntihypertensive AgentsBaroreflexBlood PressureBlood Pressure DeterminationBody Mass IndexExerciseExercise TestFemaleFollow-Up StudiesHumansHypertensionMaleOxygen ConsumptionPrognosisRetrospective StudiesAntihypertensive Agentsblood pressureexercisehumanshypertension

Identifiers

PMID29895532
OpenAlexW2808402446

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.