Evidence map›Paper›PMID 29895444›Full record

ArticleBrain stimulation

Tragus or cymba conchae? Investigating the anatomical foundation of transcutaneous auricular vagus nerve stimulation (taVNS).

Bashar W Badran, Joshua C Brown, Logan T Dowdle, Oliver J Mithoefer, Nicholas T LaBate, James Coatsworth, William H DeVries, Christopher W Austelle, Lisa M McTeague, Alfred Yu and 3 more

2 registry-linked trialsAbstract readLetterComment
In one paragraph

Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 61 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07049952 phase2 / phase3recruitingnot on this map

BabyStrong II (Stimulating the Tragus for Neural Growth): A Randomized Controlled Trial of taVNS-Paired Bottle Feeding to Improve Oral Feeding

TypeinterventionalSponsorMedical University of South CarolinaRan2025 to 2027Enrolled88ConditionsFeeding Delays, Neonates and Term InfantsArmstaVNS, NAC and taVNS, inactive taVNS, sterile water and inactive taVNS
NCT07394647 nanot yet recruitingnot on this map

Transcutaneous Auricular Vagus Nerve Stimulation for Preventing Emergence Agitation and Delirium After Pediatric Tonsillectomy and Adenoidectomy: A Randomized, Double-Blind, Interventional Study

TypeinterventionalSponsorThe First Affiliated Hospital of Zhejiang Chinese Medical UniversityRan2026 to 2026Enrolled120ConditionsEmergence Agitation, Emergence DeliriumArmsActive taVNS Group, Sham stimulation group
3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  12. Transcutaneous auricular vagus nerve stimulation improves dysautonomia in patients with hypermobile Ehlers-Danlos syndrome.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  13. Review
  14. Article
  15. Neural bridging achieves transcutaneous regulation of vagus nerve function and treatment of depressive disorders.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Bashar W BadranBrain Stimulation Lab, Medical University of South Carolina, Charleston, SC, USA; Department of Biomedical Engineering, City College of New York, New York, NY, USA; U.S. Army Research Lab, Aberdeen Proving Ground, MD, USA. Electronic address: basharwbadran@gmail.com.
Joshua C BrownBrain Stimulation Lab, Medical University of South Carolina, Charleston, SC, USA.
Logan T DowdleBrain Stimulation Lab, Medical University of South Carolina, Charleston, SC, USA.
Oliver J MithoeferBrain Stimulation Lab, Medical University of South Carolina, Charleston, SC, USA.
Nicholas T LaBateCollege of Charleston, Charleston, SC, USA.
James CoatsworthCenter for Biomedical Imaging, Medical University of South Carolina, Charleston, SC, USA.
William H DeVriesBrain Stimulation Lab, Medical University of South Carolina, Charleston, SC, USA.
Christopher W AustelleBrain Stimulation Lab, Medical University of South Carolina, Charleston, SC, USA.
Lisa M McTeagueBrain Stimulation Lab, Medical University of South Carolina, Charleston, SC, USA.
Alfred YuU.S. Army Research Lab, Aberdeen Proving Ground, MD, USA.
Marom BiksonDepartment of Biomedical Engineering, City College of New York, New York, NY, USA.
Dorothea D JenkinsDepartment of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.
Mark S GeorgeBrain Stimulation Lab, Medical University of South Carolina, Charleston, SC, USA; Department of Neurology, Medical University of South Carolina, Charleston, SC, USA; Ralph H. Johnson VA Medical Center, Charleston, SC, USA.

Funding

Treating Depression and Enhancing Locomotor Recovery Post-strokeP20GM109040 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI KAUTZ, STEVEN A. · 2014 to 2024
$23.5M
Techniques DevelopmentP2CHD086844 · NICHD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI GEORGE, MARK S · 2015 to 2024
$12.7M
NICHD NIH HHS P2C HD086844NIGMS NIH HHS P20 GM109040
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Magnetic Resonance ImagingVagus Nerve StimulationElectric StimulationHumansTranscutaneous Electric Nerve StimulationVagus NerveAuricular vagusCymba conchaetaVNSTragustVNS

Identifiers

PMID29895444
PMCPMC6607436

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.