Evidence map›Paper›PMID 29895324›Full record

ReviewInfectious diseases of poverty2018

Toxocariasis: a silent threat with a progressive public health impact.

Jia Chen, Quan Liu, Guo-Hua Liu, Wen-Bin Zheng, Sung-Jong Hong, Hiromu Sugiyama, Xing-Quan Zhu, Hany M Elsheikha

Open access · goldAbstract readReview
In one paragraph

Review in Infectious diseases of poverty, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed, 2 pooled it
15.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 2 syntheses or guidelines pooled it, 262 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Seroprevalence and Risk Factors Associated with Anti-International journal of environmental research and public health · 2026
    Article
  6. Zoonotic Relevance ofPathogens (Basel, Switzerland) · 2026
    Article
  7. Insights into the seroprevalence ofOne health (Amsterdam, Netherlands) · 2026
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Epidemiological study ofFrontiers in veterinary science · 2026
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Pathogens (Basel, Switzerland) · 2025
    Review
  19. Article
  20. Review

42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 4 countries.

Jia ChenState Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 1 Xujiaping, Yanchangbu, Lanzhou, Gansu Province, 730046, People's Republic of China.
Quan LiuMilitary Veterinary Institute, Academy of Military Medical Sciences, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, Jilin Province, People's Republic of China.
Guo-Hua LiuCollege of Veterinary Medicine, Hunan Agricultural University, Changsha, Hunan Province, People's Republic of China.
Wen-Bin ZhengState Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 1 Xujiaping, Yanchangbu, Lanzhou, Gansu Province, 730046, People's Republic of China.
Sung-Jong HongDepartment of Medical Environmental Biology, Chung-Ang University College of Medicine, Seoul, South Korea.
Hiromu SugiyamaDepartment of Parasitology, National Institute of Infectious Diseases, Tokyo, Japan.
Xing-Quan ZhuState Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 1 Xujiaping, Yanchangbu, Lanzhou, Gansu Province, 730046, People's Republic of China. xingquanzhu1@hotmail.com.ORCID http://orcid.org/0000-0003-2530-4628
Hany M ElsheikhaFaculty of Medicine and Health Sciences, School of Veterinary Medicine and Science, University of Nottingham, Loughborough, UK. hany.elsheikha@nottingham.ac.uk.
Lanzhou Veterinary Research Institute · CNAcademy of Military Medical Sciences · CNChung-Ang University · KRHunan Agricultural University · CNNational Institute of Infectious Diseases · JPNingbo University · CNUniversity of Nottingham · GB

Funding

and the Agricultural Science and Technology Innovation Program CAAS-ASTIP-2016-LVRI-03the International Science & Technology Cooperation Program of China 2013DFA31840
6 · The paper itself

Abstract

backgroundToxocariasis is a neglected parasitic zoonosis that afflicts millions of the pediatric and adolescent populations worldwide, especially in impoverished communities. This disease is caused by infection with the larvae of Toxocara canis and T. cati, the most ubiquitous intestinal nematode parasite in dogs and cats, respectively. In this article, recent advances in the epidemiology, clinical presentation, diagnosis and pharmacotherapies that have been used in the treatment of toxocariasis are reviewed. MAIN TEXT: Over the past two decades, we have come far in our understanding of the biology and epidemiology of toxocariasis. However, lack of laboratory infrastructure in some countries, lack of uniform case definitions and limited surveillance infrastructure are some of the challenges that hindered the estimation of global disease burden. Toxocariasis encompasses four clinical forms: visceral, ocular, covert and neural. Incorrect or misdiagnosis of any of these disabling conditions can result in severe health consequences and considerable medical care spending. Fortunately, multiple diagnostic modalities are available, which if effectively used together with the administration of appropriate pharmacologic therapies, can minimize any unnecessary patient morbidity.

conclusionsAlthough progress has been made in the management of toxocariasis patients, there remains much work to be done. Implementation of new technologies and better understanding of the pathogenesis of toxocariasis can identify new diagnostic biomarkers, which may help in increasing diagnostic accuracy. Also, further clinical research breakthroughs are needed to develop better ways to effectively control and prevent this serious disease.

Indexed as

Neglected DiseasesPublic HealthToxocariasisZoonosesAnimalsCatsDogsHumansToxocaraToxocara canisControlDiagnosisEpidemiologyLarva migransToxocara canisToxocariasisZoonosis

Identifiers

PMID29895324
PMCPMC5998503
OpenAlexW2806305953

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.