Evidence map›Paper›PMID 29895189›Full record

ArticleCell cycle (Georgetown, Tex.)2018

Interaction of p53 and ASPPs regulates rhesus monkey embryonic stem cells conversion to neural fate concomitant with apoptosis.

Shuang Wang, Lichuan Yang, Raoxian Bai, Shuaiwei Ren, Yuyu Niu, Yuanye Ma, Weizhi Ji, Yongchang Chen

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Shuang Wanga Yunnan Key Laboratory of Primate Biomedicine Research, Institute of Primate Translational Medicine , Kunming University of Science and Technology , Kunming , China.
Lichuan Yangc Kunming College of Life Science , University of Chinese Academy of Sciences , Kunming , China.
Raoxian Baia Yunnan Key Laboratory of Primate Biomedicine Research, Institute of Primate Translational Medicine , Kunming University of Science and Technology , Kunming , China.
Shuaiwei Rena Yunnan Key Laboratory of Primate Biomedicine Research, Institute of Primate Translational Medicine , Kunming University of Science and Technology , Kunming , China.
Yuyu Niua Yunnan Key Laboratory of Primate Biomedicine Research, Institute of Primate Translational Medicine , Kunming University of Science and Technology , Kunming , China.
Yuanye Mad Kunming Institute of Zoology , The Chinese Academy of Science , Kunming , China.
Weizhi Jia Yunnan Key Laboratory of Primate Biomedicine Research, Institute of Primate Translational Medicine , Kunming University of Science and Technology , Kunming , China.
Yongchang Chena Yunnan Key Laboratory of Primate Biomedicine Research, Institute of Primate Translational Medicine , Kunming University of Science and Technology , Kunming , China.
Kunming University of Science and Technology · CNYunnan Provincial Science and Technology Department · CNKunming Institute of Zoology · CNUniversity of Chinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The tumor suppressor p53 is a key regulator of cell apoptosis and cell cycle arrest. Recent studies show that the delicate balance of p53 expression is important for neural tube defects, neuronal degeneration, embryonic lethality, as well as differentiation and dedifferentiation. Moreover, p53 showed different regulatory patterns between rodent and primate embryonic stem cells (ESCs). However, the role of p53 and apoptosis stimulating protein of p53 (ASPP) during neural differentiation (ND) from primate ESCs is still unknown. In this study, using an FGF-2 and/or HGF selectively containing ND culture systems for rhesus monkey ESCs (rESCs), the changes of p53 and ASPPs, and p53 targets, i.e. BAX and p21, were analyzed. Our results showed that the expression patterns of ASPP1/ASPP2 and iASPP were opposite in rESCs but similar in differentiated cells, and the expression of p53 was approximately consistent with BAX, but not p21. These findings indicate that the strong expression of iASPP in ESCs and weak expression of ASPP1/ASPP2 maintain the stability of stemness; and in ND niche, unimpaired iASPP may decrease its inhibition of ASPP1/ASPP2 expression, the interaction of p53 and ASPPs causing rESCs to convert towards a neural fate concomitant with apoptosis, but not to cell cycle arrest.

Indexed as

Adaptor Proteins, Signal TransducingAnimalsApoptosisApoptosis Regulatory ProteinsCell Cycle CheckpointsCell LineCell ProliferationEmbryonic Stem CellsIntercellular Signaling Peptides and ProteinsMacaca mulattaNeurogenesisTumor Suppressor Protein p53Adaptor Proteins, Signal TransducingApoptosis Regulatory ProteinsIntercellular Signaling Peptides and ProteinsTumor Suppressor Protein p53apoptosisASPPcell cycle arrestNDP53rESCs

Identifiers

PMID29895189
PMCPMC6110590
OpenAlexW2807872538

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.