ArticleDevelopmental cognitive neuroscience2018
Increased variability of stimulus-driven cortical responses is associated with genetic variability in children with and without dyslexia.
Article in Developmental cognitive neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Orthographic depth and developmental dyslexia: a meta-analytic study.Annals of dyslexia · 2021Pooled it
- A systematic review and meta-analysis of imaging genetics studies of specific reading disorder.Cognitive neuropsychology · 2021Pooled it
- Combined accelerated theta burst stimulation and reading instruction for the treatment of persistent developmental dyslexia: methodology and preliminary findings.Frontiers in human neuroscience · 2026Article
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- Use of a predictor cue during a speech sound discrimination task in a Cntnap2 knockout rat model of autism.PloS one · 2025Article
- Individual differences in the perception of phonetic category structure predict speech-in-noise performance.The Journal of the Acoustical Society of America · 2024Article
- An executive-functions-based reading training enhances sensory-motor systems integration during reading fluency in children with dyslexia.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Auditory Category Learning in Children With Dyslexia.Journal of speech, language, and hearing research : JSLHR · 2024Article
- A Home-Based Approach to Auditory Brainstem Response Measurement: Proof-of-Concept and Practical Guidelines.Seminars in hearing · 2022Review
- Integration of visual motion and orientation signals in dyslexic children: an equivalent noise approach.Royal Society open science · 2022Article
- Electrophysiological correlates of perceptual prediction error are attenuated in dyslexia.Neuropsychologia · 2022Article
- Theory-driven classification of reading difficulties from fMRI data using Bayesian latent-mixture models.NeuroImage · 2021Article
- The Polygenic Nature and Complex Genetic Architecture of Specific Learning Disorder.Brain sciences · 2021Review
- Identification of Phonology-Related Genes and Functional Characterization of Broca's and Wernicke's Regions in Language and Learning Disorders.Frontiers in neuroscience · 2021Article
- An Evolutionary Perspective of Dyslexia, Stress, and Brain Network Homeostasis.Frontiers in human neuroscience · 2020Review
- Disrupted left fusiform response to print in beginning kindergartners is associated with subsequent reading.NeuroImage. Clinical · 2019Article
Corrections and comments
- Erratum issuedErratum.2020
Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Individuals with dyslexia exhibit increased brainstem variability in response to sound. It is unknown as to whether increased variability extends to neocortical regions associated with audition and reading, extends to visual stimuli, and whether increased variability characterizes all children with dyslexia or, instead, a specific subset of children. We evaluated the consistency of stimulus-evoked neural responses in children with (N = 20) or without dyslexia (N = 12) as measured by magnetoencephalography (MEG). Approximately half of the children with dyslexia had significantly higher levels of variability in cortical responses to both auditory and visual stimuli in multiple nodes of the reading network. There was a significant and positive relationship between the number of risk alleles at rs6935076 in the dyslexia-susceptibility gene KIAA0319 and the degree of neural variability in primary auditory cortex across all participants. This gene has been linked with neural variability in rodents and in typical readers. These findings indicate that unstable representations of auditory and visual stimuli in auditory and other reading-related neocortical regions are present in a subset of children with dyslexia and support the link between the gene KIAA0319 and the auditory neural variability across children with or without dyslexia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.