ArticleDevelopmental cognitive neuroscience2018
Developmental variation in regional brain iron and its relation to cognitive functions in childhood.
Article in Developmental cognitive neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Pooled it
- The role of subcortical brain tissue iron as an indicator of dopamine neurophysiology in adolescent cannabis use.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Developmental variation in basal ganglia tissue iron, neurocognitive functioning, and impulsivity is associated with substance use trajectories in youth.Nature communications · 2026Article
- Ferroptosis and Alzheimer's disease: a new insight into neurodegeneration.Frontiers in immunology · 2026Review
- Developmental variation in dopamine neurobiology, neurocognitive functioning, and impulsivity shape substance use trajectories in youth.bioRxiv : the preprint server for biology · 2025Article
- Maternal Prenatal Psychological Stress and Iron Levels in the Fetal Brain.Developmental psychobiology · 2025Article
- Adolescent maturation of dorsolateral prefrontal cortex glutamate:GABA and cognitive function is supported by dopamine-related neurobiology.Molecular psychiatry · 2025Article
- Maturation of striatal dopamine supports the development of habitual behavior through adolescence.bioRxiv : the preprint server for biology · 2025Article
- Leveraging ultra-high field (7T) MRI in psychiatric research.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Iron imbalance in neurodegeneration.Molecular psychiatry · 2024Review
- The Role of Calcium and Iron Homeostasis in Parkinson's Disease.Brain sciences · 2024Review
- Multivariate and regional age-related change in basal ganglia iron in neonates.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Developmental coupling of brain iron and intrinsic activity in infants during the first 150 days.Developmental cognitive neuroscience · 2023Article
- Article
- Development of Iron Status Measures during Youth: Associations with Sex, Neighborhood Socioeconomic Status, Cognitive Performance, and Brain Structure.The American journal of clinical nutrition · 2023Article
- Gestational and postnatal age associations for striatal tissue iron deposition in early infancy.bioRxiv : the preprint server for biology · 2023Article
- Iron Deposition in Brain: Does Aging Matter?International journal of molecular sciences · 2022Review
- Analysis of deep grey nuclei susceptibility in early childhood: a quantitative susceptibility mapping and R2* study at 3 Tesla.Neuroradiology · 2022Article
- Contributions of dopamine-related basal ganglia neurophysiology to the developmental effects of incentives on inhibitory control.Developmental cognitive neuroscience · 2022Article
- R2* and quantitative susceptibility mapping in deep gray matter of 498 healthy controls from 5 to 90 years.Human brain mapping · 2021Article
Corrections and comments
- Erratum issuedErratum.2020
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Non-heme iron is a vital metabolic cofactor for many core processes of brain development including myelination, dendritogenesis, and neurotransmitter synthesis, and accumulates in the brain with age. However, little is known about development-related differences in brain iron and its association with emerging cognitive abilities during formative years. In this study, we estimated brain iron via R2* relaxometry in children ages 7-16 (N = 57; 38 females) and examined its relation to age-related differences in cognitive ability. As we hypothesized, age correlated positively with iron content in the hippocampus and across subregions of the basal ganglia. The magnitude of age differences in iron content differed between regions such that the largest effects were observed in basal ganglia subregions: globus pallidus, substantia nigra, caudate nucleus, and putamen, as compared to values obtained for the hippocampus and red nucleus. We did not observe sex or hemispheric differences in iron content. Notably, greater brain iron content was associated with both faster processing speed and higher general intelligence, and shared 21.4% of the age-related improvement in processing speed and 12.5% of the improvement in general intelligence. These results suggest that non-heme iron plays a central neurobiological role in the development of critical cognitive abilities during childhood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.