Evidence map›Paper›PMID 29894852›Full record

ArticleBiosensors & bioelectronics2018

A compact, low-cost, quantitative and multiplexed fluorescence detection platform for point-of-care applications.

Uwadiae Obahiagbon, Joseph T Smith, Meilin Zhu, Benjamin A Katchman, Hany Arafa, Karen S Anderson, Jennifer M Blain Christen

Abstract read
In one paragraph

Article in Biosensors & bioelectronics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Uwadiae ObahiagbonSchool of Electrical, Computer and Energy Engineering at Arizona State University, Suite 334, Goldwater Center, Tempe, AZ 85287, USA.
Joseph T SmithSchool of Electrical, Computer and Energy Engineering at Arizona State University, Suite 334, Goldwater Center, Tempe, AZ 85287, USA; Center for Personalized Diagnostics, Biodesign Institute at Arizona State University, Tempe, AZ 85281, USA.
Meilin ZhuCenter for Personalized Diagnostics, Biodesign Institute at Arizona State University, Tempe, AZ 85281, USA.
Benjamin A KatchmanCenter for Personalized Diagnostics, Biodesign Institute at Arizona State University, Tempe, AZ 85281, USA.
Hany ArafaSchool of Electrical, Computer and Energy Engineering at Arizona State University, Suite 334, Goldwater Center, Tempe, AZ 85287, USA.
Karen S AndersonCenter for Personalized Diagnostics, Biodesign Institute at Arizona State University, Tempe, AZ 85281, USA.
Jennifer M Blain ChristenSchool of Electrical, Computer and Energy Engineering at Arizona State University, Suite 334, Goldwater Center, Tempe, AZ 85287, USA. Electronic address: jennifer.blainchristen@asu.edu.

Funding

Rapid Point of Care Detection of HPV-Associated MalignanciesUH3CA211415 · NCI · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI ANDERSON, KAREN SUE, BRENNER, DEAN E. · 2019 to 2022
$2.4M
Rapid Point of Care Detection of HPV-Associated MalignanciesUG3CA211415 · NCI · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI ANDERSON, KAREN SUE, BRENNER, DEAN E. · 2017 to 2018
$715k
NCI NIH HHS UG3 CA211415NCI NIH HHS UH3 CA211415
6 · The paper itself

Abstract

An effective method of combating infectious diseases is the deployment of hand-held devices at the point-of-care (POC) for screening or self-monitoring applications. There is a need for very sensitive, low-cost and quantitative diagnostic devices. In this study, we present a low-cost, multiplexed fluorescence detection platform that has a high sensitivity and wide dynamic range. Our system features inexpensive 3 × 3 mm interference filters with a high stopband rejection, sharp transition edges, and greater than 90% transmission in the passband. In addition to the filters, we improve signal-to-noise ratio by leveraging time for accuracy using a charge-integration-based readout. The fluorescence sensing platform provides a sensitivity to photon flux of ∼1×10

Indexed as

AntibodiesBiomarkersBiosensing TechniquesColorimetryEarly Detection of CancerFemaleHumansPapillomavirus E7 ProteinsPoint-of-Care SystemsUterine Cervical NeoplasmsAntibodiesBiomarkersoncogene protein E7, Human papillomavirus type 16Papillomavirus E7 ProteinsColorimetryDiagnosticsFluorescenceLimit of detectionMultiplexedPoint-of-care

Identifiers

PMID29894852
PMCPMC6095205

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.