Evidence map›Paper›PMID 29894771›Full record

ArticleNeuropharmacology2018

CNS distribution, signalling properties and central effects of G-protein coupled receptor 4.

P S Hosford, V Mosienko, K Kishi, G Jurisic, K Seuwen, B Kinzel, M G Ludwig, J A Wells, I N Christie, L Koolen and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.

  1. CONature communications · 2022
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Intrinsic Molecular Proton Sensitivity Underlies GPR4 Effects on Retrotrapezoid Nucleus Neuronal Activation and COThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  14. Article
  15. Review
  16. Review
  17. pH and proton-sensitive receptors in brain ischemia.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Article
  18. Physiological relevance of proton-activated GPCRs.Pflugers Archiv : European journal of physiology · 2022
    Review
  19. Review
  20. Central respiratory chemoreception.Handbook of clinical neurology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

P S HosfordCentre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, WC1E 6BT, UK.
V MosienkoPhysiology, Pharmacology and Neuroscience, University of Bristol, BS8 1TD, UK.
K KishiPhysiology, Pharmacology and Neuroscience, University of Bristol, BS8 1TD, UK.
G JurisicNovartis Institutes for Biomedical Research, CH-4002 Basel, Switzerland.
K SeuwenNovartis Institutes for Biomedical Research, CH-4002 Basel, Switzerland.
B KinzelNovartis Institutes for Biomedical Research, CH-4002 Basel, Switzerland.
M G LudwigNovartis Institutes for Biomedical Research, CH-4002 Basel, Switzerland.
J A WellsCentre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, WC1E 6BT, UK.
I N ChristieCentre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, WC1E 6BT, UK.
L KoolenPhysiology, Pharmacology and Neuroscience, University of Bristol, BS8 1TD, UK.
A P AbdalaPhysiology, Pharmacology and Neuroscience, University of Bristol, BS8 1TD, UK.
B H LiuPhysiology, Pharmacology and Neuroscience, University of Bristol, BS8 1TD, UK.
A V GourineCentre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, WC1E 6BT, UK.
A G TeschemacherPhysiology, Pharmacology and Neuroscience, University of Bristol, BS8 1TD, UK. Electronic address: Anja.Teschemacher@bristol.ac.uk.
S KasparovPhysiology, Pharmacology and Neuroscience, University of Bristol, BS8 1TD, UK; Baltic Federal University, Kaliningrad 236041, Russian Federation. Electronic address: Sergey.Kasparov@bristol.ac.uk.
University of Bristol · GBNovartis (Switzerland) · CHUniversity College London · GBImmanuel Kant Baltic Federal University · RU

Funding

CRCNS: Modeling the respiratory-sympathetic coupling in neurogenic hypertensionR01AT008632 · NCCIH · INDIANA UNIVERSITY INDIANAPOLIS · PI MOLKOV, YAROSLAV · 2015 to 2019
$1.4M
Medical Research Council MR/L020661/1NCCIH NIH HHS R01 AT008632Wellcome Trust 095064Wellcome Trust 200893/Z/16/Z
6 · The paper itself

Abstract

Information on the distribution and biology of the G-protein coupled receptor 4 (GPR4) in the brain is limited. It is currently thought that GPR4 couples to G

Indexed as

AnimalsBrainCentral Nervous System AgentsCerebrovascular CirculationCyclic AMPEndotheliumHEK293 CellsHemodynamicsHumansHuman Umbilical Vein Endothelial CellsHydrogen-Ion ConcentrationLactic AcidMaleMice, Inbred C57BLMice, TransgenicOxadiazolesCentral Nervous System AgentsCyclic AMPGPR4 protein, humanGPR4 protein, mouseGpr4 protein, ratLactic AcidNE-52-qq57OxadiazolesOxygenPiperidinesPyrazolesReceptors, G-Protein-CoupledAntagonistDistributionGPR4LactateModulationRespiration

Identifiers

PMID29894771
PMCPMC6063991
OpenAlexW2805197286

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.