SynthesisPediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies2018
Neurologic Outcomes After Extracorporeal Membrane Oxygenation: A Systematic Review.
Synthesis in Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Functional assessment in children undergoing extracorporeal membrane oxygenation using the functional status scale: a scoping review.Frontiers in pediatrics · 2026Pooled it
- Long-term follow-up of neuropsychological complications in neonates undergoing extracorporeal membrane oxygenation: a systematic review and meta-analysis.BMC pediatrics · 2024Pooled it
- A systematic review of the impact of intensive care admissions on post discharge cognition in children.European journal of pediatrics · 2021Pooled it
- Long-term neurodevelopment in children born with esophageal atresia: a systematic review.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2021Pooled it
- Ultra-Low-Field Portable Magnetic Resonance Imaging Feasibility and Safety in Pediatric and Neonatal Extracorporeal Membrane Oxygenation: A Single-Center Year-Long Experience.Journal of the American Heart Association · 2025Trial
- Multimodal neuromonitoring modalities of neonatal patients on extracorporeal membrane oxygenation.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Long-term health-related quality of life in pediatric ECMO survivors: a prospective controlled study.Pediatric research · 2026Article
- Automated pupillometry for the prediction of neurologic outcomes in children requiring extracorporeal membrane oxygenation (ECMO).European journal of pediatrics · 2026Observational
- Chinese expert consensus for neurological monitoring and long-term follow-up in neonatal patients supported on extracorporeal membrane oxygenation (ECMO) (2025): a protocol.Frontiers in medicine · 2026Article
- Exploratory deep-learning-driven early risk stratification of significant neurological injury in pediatric extracorporeal membrane oxygenation.Frontiers in digital health · 2026Article
- Navigating end-of-life decision-making on ECLS discontinuation in children: insights from the international ENSURE survey.European journal of pediatrics · 2025Article
- ECMO in Refractory Septic Shock: Patient Selection, Timing and Hemodynamic Targets.Journal of clinical medicine · 2025Review
- Neonatal seizures during extra corporeal membrane oxygenation support.European journal of pediatrics · 2024Article
- Exploratory factor analysis yields grouping of brain injury biomarkers significantly associated with outcomes in neonatal and pediatric ECMO.Scientific reports · 2024Article
- Parents' knowledge and attitudes towards extracorporeal membrane oxygenation and their post-traumatic stress symptoms.Scientific reports · 2024Article
- Long-term follow-up of patients with congenital diaphragmatic hernia.World journal of pediatric surgery · 2024Review
- Lessons Learned in Neurodevelopmental Outcomes Research in Children Following Extracorporeal Membrane Oxygenation.Journal of neurosurgical anesthesiology · 2023Review
- Comparison of clinical characteristics and healthcare resource use of pediatric chronic and non-chronic critically ill patients in intensive care units: a retrospective national registry study.Frontiers in pediatrics · 2023Article
- Congenital diaphragmatic hernia.Nature reviews. Disease primers · 2022Review
- Cognitive and Psychological Outcomes Following Pediatric Cardiac Arrest.Frontiers in pediatrics · 2022Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectivesThe goal of this systematic review of the literature was to summarize neurologic outcomes following neonatal and pediatric extracorporeal membrane oxygenation. DATA SOURCES: We conducted electronic searches of PubMed, Scopus, Web of Science, CINAHL, Cochrane, and EMBASE. STUDY SELECTION: Inclusion criteria included publication dates 2000-2016, patient ages 0-18 years, and use of standardized measures to evaluate outcomes after extracorporeal membrane oxygenation. DATA EXTRACTION: We identified 3,497 unique citations; 60 full-text articles were included in the final review. DATA SYNTHESIS: Studies evaluated patients with congenital diaphragmatic hernia (7), cardiac disease (8), cardiac arrest (13), and mixed populations (32). Follow-up was conducted at hospital discharge in 10 studies (17%) and at a median of 26 months (interquartile range, 8-61 mo) after extracorporeal membrane oxygenation in 50 studies (83%). We found 55 outcome measures that assessed overall health and function (4), global cognitive ability (7), development (4), motor function (5), adaptive function (2), behavior/mood (6), hearing (2), quality of life (2), school achievement (5), speech and language (6), learning and memory (4), and attention and executive function (8). Overall, 10% to as many as 50% of children scored more than 2 SDS below the population mean on cognitive testing. Behavior problems were identified in 16-46% of children tested, and severe motor impairment was reported in 12% of children. Quality of life of former extracorporeal membrane oxygenation patients evaluated at school age or adolescence ranged from similar to healthy peers, to 31-53% having scores more than 1 SD below the population mean.
conclusionsThis systematic review of the literature suggests that children who have undergone extracorporeal membrane oxygenation suffer from a wide range of disabilities. A meta-analysis was not feasible due to heterogeneity in pathologies, outcome measures, and age at follow-up, underscoring the importance of developing and employing a core set of outcomes measures in future extracorporeal membrane oxygenation studies.
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Registered trials
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