Observational studyPediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies2018
Corrected QT Interval Prolongation in Hospitalized Pediatric Patients Receiving Methadone.
Observational study in Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- Evaluating the Efficacy and Safety of Erythromycin for the Treatment of Gastroparesis in Infants and Children.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2025Article
- Methadone: applications in pediatric anesthesiology and critical care medicine.Journal of anesthesia · 2021Review
- Review
- Drug-induced prolonged corrected QT interval in patients with methadone and opium overdose.Substance abuse treatment, prevention, and policy · 2019Article
- Short-acting versus long-acting opioids for pediatric postoperative pain management.Expert review of clinical pharmacologyReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectivesMethadone is often used in pediatric patients to prevent or treat opioid withdrawal after prolonged sedation. Prolonged corrected QT interval is an important adverse effect of methadone because it can progress to torsades de pointes, a potentially fatal dysrhythmia. The prevalence of corrected QT interval prolongation and contributing risk factors are not well defined in hospitalized pediatric patients receiving methadone. The study purpose was to identify the frequency and risk factors of corrected QT interval prolongation in hospitalized pediatric patients receiving methadone.
designRetrospective cohort study.
settingTertiary academic pediatric hospital, University of California Davis Children's Hospital, Sacramento, CA. PATIENTS: Cohort of 89 pediatric patients (birth to 18 yr) who received at least one dose of methadone while hospitalized.
interventionsRetrospective data over 7.5 years were obtained from the electronic health record. MEASUREMENTS AND MAIN
resultsFrom the cohort, 45 patients (50.6%) had documented corrected QT interval prolongation (≥ 450 ms) during the study period. No episodes of torsades de pointes were identified. In univariate analyses, higher maximum methadone doses were associated with a prolonged corrected QT interval (0.98 vs 0.59 mg/kg/d; odds ratio, 2.56; 1.15-5.70). Corrected QT interval prolongation occurred more frequently in patients with cardiac disease (63% vs 41%; p = 0.10). No factors were statistically significant in the multivariate analysis.
conclusionsIn hospitalized pediatric patients receiving methadone, corrected QT interval prolongation was common, but no episodes of torsades de pointes were documented. Risk factors that have been identified in adults were not associated with prolongation in our study population.
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