Evidence map›Paper›PMID 29894417›Full record

ReviewPancreas2018

Advances in Diagnostic and Intraoperative Molecular Imaging of Pancreatic Cancer.

Willemieke S Tummers, Juergen K Willmann, Bert A Bonsing, Alexander L Vahrmeijer, Sanjiv S Gambhir, Rutger-Jan Swijnenburg

Abstract readReview
In one paragraph

Review in Pancreas, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Willemieke S Tummers
Juergen K Willmann
Bert A BonsingDepartment of Surgery, Leiden University Medical Center, Leiden, the Netherlands.
Alexander L VahrmeijerDepartment of Surgery, Leiden University Medical Center, Leiden, the Netherlands.
Sanjiv S Gambhir
Rutger-Jan SwijnenburgDepartment of Surgery, Leiden University Medical Center, Leiden, the Netherlands.

Funding

High Sensitivity Molecular Ultrasound Imaging in Pancreatic CancerR21EB022770 · NIBIB · STANFORD UNIVERSITY · PI DAHL, JEREMY · 2016 to 2017
$435k
Pancreatic Ductal Adenocarcinoma Targeted Ultrasound Contrast Agent DevelopmentR41CA203090 · NCI · NUVOX PHARMA, LLC · PI UNGER, EVAN CHARLES, WILLMANN, JUERGEN KARL · 2016 to 2016
$298k
NCI NIH HHS R41 CA203090NIBIB NIH HHS R21 EB022770
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis. To improve outcomes, there is a critical need for improved tools for detection, accurate staging, and resectability assessment. This could improve patient stratification for the most optimal primary treatment modality. Molecular imaging, used in combination with tumor-specific imaging agents, can improve established imaging methods for PDAC. These novel, tumor-specific imaging agents developed to target specific biomarkers have the potential to specifically differentiate between malignant and benign diseases, such as pancreatitis. When these agents are coupled to various types of labels, this type of molecular imaging can provide integrated diagnostic, noninvasive imaging of PDAC as well as image-guided pancreatic surgery. This review provides a detailed overview of the current clinical imaging applications, upcoming molecular imaging strategies for PDAC, and potential targets for imaging, with an emphasis on intraoperative imaging applications.

Indexed as

Carcinoma, Pancreatic DuctalDiagnosis, DifferentialHumansMolecular ImagingMonitoring, IntraoperativePancreasPancreatic NeoplasmsPrognosisReproducibility of ResultsSensitivity and Specificity

Identifiers

PMID29894417
PMCPMC6003672

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.