Evidence map›Paper›PMID 29894205›Full record

ArticleAmerican journal of respiratory cell and molecular biology2018

Elafin Treatment Rescues EGFR-Klf4 Signaling and Lung Cell Survival in Ventilated Newborn Mice.

Miguel A Alejandre Alcazar, Mark Kaschwich, Robert Ertsey, Stefanie Preuss, Carlos Milla, Sana Mujahid, Juliet Masumi, Suleman Khan, Lucia M Mokres, Lu Tian and 4 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

  1. Novel netrin-1-Unc5b-Klf4 axis balances AT2 survival in experimental bronchopulmonary dysplasia.American journal of respiratory cell and molecular biology · 2026
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  15. Update in Critical Care and Acute Respiratory Distress Syndrome 2018.American journal of respiratory and critical care medicine · 2019
    Article
  16. Mechanisms of Ventilator-induced Lung Injury: Is the Elafin in the Room?American journal of respiratory cell and molecular biology · 2018
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Miguel A Alejandre Alcazar1 Department of Pediatrics, Stanford University School of Medicine, Stanford, California; and.
Mark Kaschwich1 Department of Pediatrics, Stanford University School of Medicine, Stanford, California; and.
Robert Ertsey1 Department of Pediatrics, Stanford University School of Medicine, Stanford, California; and.
Stefanie Preuss1 Department of Pediatrics, Stanford University School of Medicine, Stanford, California; and.
Carlos Milla1 Department of Pediatrics, Stanford University School of Medicine, Stanford, California; and.
Sana Mujahid1 Department of Pediatrics, Stanford University School of Medicine, Stanford, California; and.
Juliet Masumi1 Department of Pediatrics, Stanford University School of Medicine, Stanford, California; and.
Suleman Khan1 Department of Pediatrics, Stanford University School of Medicine, Stanford, California; and.
Lucia M Mokres1 Department of Pediatrics, Stanford University School of Medicine, Stanford, California; and.
Lu Tian1 Department of Pediatrics, Stanford University School of Medicine, Stanford, California; and.
Jasmine Mohr2 Department of Pediatric and Adolescent Medicine, Center of Molecular Medicine Cologne, University Hospital of Cologne, Cologne, Germany.
Dharmesh V Hirani2 Department of Pediatric and Adolescent Medicine, Center of Molecular Medicine Cologne, University Hospital of Cologne, Cologne, Germany.
Marlene Rabinovitch1 Department of Pediatrics, Stanford University School of Medicine, Stanford, California; and.
Richard D Bland1 Department of Pediatrics, Stanford University School of Medicine, Stanford, California; and.
Stanford University · USUniversity Hospital Cologne · DE

Funding

The Cellular Response to Elafin in PAHP01HL108797 · NHLBI · STANFORD UNIVERSITY · PI NOLAN, GARRY P · 2011 to 2021
$19.7M
Mechanical Ventilation of Newborn Mice:Impact on Alveolarization and Lung ElastinR01HL086631 · NHLBI · STANFORD UNIVERSITY · PI BLAND, RICHARD DAVID · 2008 to 2011
$1.9M
NHLBI NIH HHS P01 HL108797NHLBI NIH HHS R01 HL086631
6 · The paper itself

Abstract

Mechanical ventilation with O

Indexed as

AnimalsAnimals, NewbornApoptosisBronchopulmonary DysplasiaCells, CulturedCell SurvivalElafinErbB ReceptorsHumansInfant, NewbornInfant, PrematureKruppel-Like Factor 4Kruppel-Like Transcription FactorsLongitudinal StudiesMiceMice, Inbred BALB CElafinErbB ReceptorsKLF4 protein, humanKlf4 protein, mouseKruppel-Like Factor 4Kruppel-Like Transcription FactorsPancreatic ElastaseProtease Inhibitorsbronchopulmonary dysplasiaEGFR and Klf4 proteinselastase inhibitionlung growth arrestneonatal chronic lung disease

Identifiers

PMID29894205
PMCPMC6236693
OpenAlexW2807967133

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.