Evidence map›Paper›PMID 29893992›Full record

ArticleMagnetic resonance in medicine2018

Removal of hyperpolarized

Andrew D Hahn, Jeff Kammerman, Sean B Fain

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Design and Implementation of a Multi-Center Trial ofJournal of magnetic resonance imaging : JMRI · 2025
    Article
  2. Article
  3. Functional Pulmonary Imaging.Journal of magnetic resonance imaging : JMRI · 2025
    Review
  4. A thermally polarized, dissolved-phaseJournal of magnetic resonance (San Diego, Calif. : 1997) · 2025
    Article
  5. Article
  6. Lung Volume Dependence and Repeatability of HyperpolarizedRadiology. Cardiothoracic imaging · 2023
    Article
  7. HyperpolarizedRadiology · 2022
    Article
  8. PediatricJournal of magnetic resonance imaging : JMRI · 2022
    Article
  9. Article
  10. HyperpolarizedInternational journal of radiation oncology, biology, physics · 2021
    Article
  11. Article
  12. In vivo methods and applications of xenon-129 magnetic resonance.Progress in nuclear magnetic resonance spectroscopy · 2021
    Review
  13. Preclinical hyperpolarizedNMR in biomedicine · 2020
    Article
  14. Repeatability of regional pulmonary functional metrics of HyperpolarizedJournal of magnetic resonance imaging : JMRI · 2019
    Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Andrew D HahnDepartment of Medical Physics, University of Wisconsin, Madison, Wisconsin.
Jeff KammermanDepartment of Medical Physics, University of Wisconsin, Madison, Wisconsin.
Sean B FainDepartment of Medical Physics, University of Wisconsin, Madison, Wisconsin.

Funding

University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
Using MRI To Visualize Regional Therapy Response In Idiopathic Pulmonary FibrosisR01HL126771 · NHLBI · DUKE UNIVERSITY · PI Bastiaan Driehuys · 2015 to 2026
$6.6M
XeBox-E10 Gas Polarizer for Functional MRI of Pediatric Lung DiseaseS10OD016394 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI FAIN, SEAN BEDILION · 2013 to 2013
$600k
NCATS NIH HHS UL1 TR000427NCATS NIH HHS UL1 TR002373NHLBI NIH HHS R01 HL126771NIH HHS NIH/NCATS UL1 TR000427NIH HHS NIH/NCRR 1 S10 OD016394NIH HHS NIH/NHLBI R01 HL126771NIH HHS S10 OD016394
6 · The paper itself

Abstract

purposeA novel technique is presented for retrospective estimation and removal of gas-phase hyperpolarized Xenon-129 (HP

methodsDigital lung phantom and human subject experiments (N = 8 healthy; N = 1 with idiopathic pulmonary fibrosis) were acquired with 3D radial trajectory and 1-point Dixon spectroscopic imaging to assess the correction method for mitigating barrier and RBC imaging artifacts. Dependence of performance on TE, image SNR, and gas contamination level were characterized. Inter- and intra-subject variation in the dissolved-phase ratios were quantified and compared to human subject experiments before and after correction.

resultsGas contamination resulted in image artifacts similar to those in disease that were mitigated after correction in both simulated and human subject data; for simulation experiments performance varied with TE, but was independent of image SNR and the amount of gas contamination. Artifacts and variation of barrier and RBC components were reduced after correction in both simulation and healthy human lungs (barrier, P = 0.01; RBC, P = 0.045).

conclusionThe proposed technique significantly reduced regional variations in barrier and RBC ratios, separated using a 1-point Dixon approach, with improved accuracy of dissolved-phase HP

Indexed as

SpectrophotometryAdultAgedArtifactsComputer SimulationErythrocytesFemaleGasesHumansIdiopathic Pulmonary FibrosisImage Processing, Computer-AssistedImaging, Three-DimensionalLungMaleMiddle AgedPhantoms, ImagingGasesXenon-129Xenon Isotopesartifact correctionhyperpolarized MRIidiopathic pulmonary fibrosislungspectroscopic imagingxenon MRI

Identifiers

PMID29893992
PMCPMC6291357

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.