ArticleJournal of experimental botany2018
The Nicotiana tabacum ABC transporter NtPDR3 secretes O-methylated coumarins in response to iron deficiency.
Article in Journal of experimental botany, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 49 citations in OpenAlex.
- RsWRKY15-RsPDR12 module regulates Cd uptake and accumulation by promoting Cd efflux in radish (Raphanus sativus L.).Molecular horticulture · 2026Article
- RsWRKY75 promotes ROS scavenging and cadmium efflux via activating the transcription of RsAPX1 and RsPDR8 in radish (Raphanus sativus L.).Plant cell reports · 2025Article
- Shedding light on iron nutrition: exploring intersections of transcription factor cascades in light and iron deficiency signaling.Journal of experimental botany · 2025Review
- The biosynthetic pathway of coumarin and its genetic regulation in response to biotic and abiotic stresses.Frontiers in plant science · 2025Review
- Genomic characterisation of the metal tolerance protein gene family and elucidation of functional role in heavy metal tolerance and accumulation inFrontiers in plant science · 2025Article
- Comparative metabolic profiling of the mycelium and fermentation broth of Penicillium restrictum from Peucedanum praeruptorum rhizosphere.Environmental microbiology reports · 2024Article
- GmABCG5, an ATP-binding cassette G transporter gene, is involved in the iron deficiency response in soybean.Frontiers in plant science · 2023Article
- Production of Recombinant Glycoproteins in Nicotiana tabacum BY-2 Suspension Cells.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Comparative Transcriptomics Unveil the Crucial Genes Involved in Coumarin Biosynthesis inFrontiers in plant science · 2022Article
- 2021 update on ATP-binding cassette (ABC) transporters: how they meet the needs of plants.Plant physiology · 2021Review
- Adaptive mechanisms of plant specialized metabolism connecting chemistry to function.Nature chemical biology · 2021Review
- Unravelling the Puzzle of Anthranoid Metabolism in Living Plant Cells Using Spectral Imaging Coupled to Mass Spectrometry.Metabolites · 2021Article
- Autophagy is essential for optimal translocation of iron to seeds in Arabidopsis.Journal of experimental botany · 2019Article
- Towards Identification of the Substrates of ATP-Binding Cassette Transporters.Plant physiology · 2018Review
- The Phenylpropanoid Case - It Is Transport That Matters.Frontiers in plant science · 2018Article
- The Early Response to Urea, Nitrate, or Ammonium and Iron Resupply in Tomato Roots Highlights the Induction of FER, bHLHs, UMAMITs, and MATEs.Physiologia plantarumArticle
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although iron is present in large amounts in the soil, its poor solubility means that plants have to use various strategies to facilitate its uptake. In this study, we show that expression of NtPDR3/NtABCG3, a Nicotiana tabacum plasma-membrane ABC transporter in the pleiotropic drug resistance (PDR) subfamily, is strongly induced in the root epidermis under iron deficiency conditions. Prevention of NtPDR3 expression resulted in N. tabacum plants that were less tolerant to iron-deficient conditions, displaying stronger chlorosis and slower growth than those of the wild-type when not supplied with iron. Metabolic profiling of roots and root exudates revealed that, upon iron deficiency, secretion of catechol-bearing O-methylated coumarins such as fraxetin, hydroxyfraxetin, and methoxyfraxetin to the rhizosphere was compromised in NtPDR3-silenced plants. However, exudation of flavins such as riboflavin was not markedly affected by NtPDR3-silencing. Expression of NtPDR3 in N. tabacum Bright Yellow-2 (BY-2) cells resulted in altered intra- and extracellular coumarin pools, supporting coumarin transport by this transporter. The results demonstrate that N. tabacum secretes both coumarins and flavins in response to iron deficiency and that NtPDR3 plays an essential role in the plant response to iron deficiency by mediating secretion of O-methylated coumarins to the rhizosphere.
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