Evidence map›Paper›PMID 29893649›Full record

ArticleRadiology2018

Non-Small-Cell Lung Cancer: Feasibility of Intratumoral Radiofrequency Hyperthermia-enhanced Herpes Simplex Virus Thymidine Kinase Gene Therapy.

Jiansong Ji, Qiaoyou Weng, Feng Zhang, Fu Xiong, Yin Jin, Junguo Hui, Jingjing Song, Jun Gao, Minjiang Chen, Qiang Li and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Molecular imaging-monitored radiofrequency hyperthermia-enhanced intratumoral herpes simplex virus-thymidine kinase gene therapy for rat orthotopic ovarian cancer.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2020
    Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Jiansong JiFrom the Image-Guided Bio-Molecular Interventions Research and Division of Interventional Radiology, Department of Radiology, University of Washington School of Medicine, 850 Republican St, S470, Seattle, WA 98109 (J.J., Q.W., F.Z., F.X., Y.J., J.S., J.G., M.C., Q.L., D.S., X.Y.); Key Laboratory of Imaging Diagnosis and Minimally Invasive Interventional Research of Zhejiang Province, Department of Radiology, Zhejiang University Lishui Hospital, Lishui, Zhejiang, China (J.J., Q.W., J.H., J.S., M.C., Q.L.); and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China (Y.J., X.Y.).
Qiaoyou WengFrom the Image-Guided Bio-Molecular Interventions Research and Division of Interventional Radiology, Department of Radiology, University of Washington School of Medicine, 850 Republican St, S470, Seattle, WA 98109 (J.J., Q.W., F.Z., F.X., Y.J., J.S., J.G., M.C., Q.L., D.S., X.Y.); Key Laboratory of Imaging Diagnosis and Minimally Invasive Interventional Research of Zhejiang Province, Department of Radiology, Zhejiang University Lishui Hospital, Lishui, Zhejiang, China (J.J., Q.W., J.H., J.S., M.C., Q.L.); and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China (Y.J., X.Y.).
Feng ZhangFrom the Image-Guided Bio-Molecular Interventions Research and Division of Interventional Radiology, Department of Radiology, University of Washington School of Medicine, 850 Republican St, S470, Seattle, WA 98109 (J.J., Q.W., F.Z., F.X., Y.J., J.S., J.G., M.C., Q.L., D.S., X.Y.); Key Laboratory of Imaging Diagnosis and Minimally Invasive Interventional Research of Zhejiang Province, Department of Radiology, Zhejiang University Lishui Hospital, Lishui, Zhejiang, China (J.J., Q.W., J.H., J.S., M.C., Q.L.); and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China (Y.J., X.Y.).
Fu XiongFrom the Image-Guided Bio-Molecular Interventions Research and Division of Interventional Radiology, Department of Radiology, University of Washington School of Medicine, 850 Republican St, S470, Seattle, WA 98109 (J.J., Q.W., F.Z., F.X., Y.J., J.S., J.G., M.C., Q.L., D.S., X.Y.); Key Laboratory of Imaging Diagnosis and Minimally Invasive Interventional Research of Zhejiang Province, Department of Radiology, Zhejiang University Lishui Hospital, Lishui, Zhejiang, China (J.J., Q.W., J.H., J.S., M.C., Q.L.); and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China (Y.J., X.Y.).
Yin JinFrom the Image-Guided Bio-Molecular Interventions Research and Division of Interventional Radiology, Department of Radiology, University of Washington School of Medicine, 850 Republican St, S470, Seattle, WA 98109 (J.J., Q.W., F.Z., F.X., Y.J., J.S., J.G., M.C., Q.L., D.S., X.Y.); Key Laboratory of Imaging Diagnosis and Minimally Invasive Interventional Research of Zhejiang Province, Department of Radiology, Zhejiang University Lishui Hospital, Lishui, Zhejiang, China (J.J., Q.W., J.H., J.S., M.C., Q.L.); and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China (Y.J., X.Y.).
Junguo HuiFrom the Image-Guided Bio-Molecular Interventions Research and Division of Interventional Radiology, Department of Radiology, University of Washington School of Medicine, 850 Republican St, S470, Seattle, WA 98109 (J.J., Q.W., F.Z., F.X., Y.J., J.S., J.G., M.C., Q.L., D.S., X.Y.); Key Laboratory of Imaging Diagnosis and Minimally Invasive Interventional Research of Zhejiang Province, Department of Radiology, Zhejiang University Lishui Hospital, Lishui, Zhejiang, China (J.J., Q.W., J.H., J.S., M.C., Q.L.); and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China (Y.J., X.Y.).
Jingjing SongFrom the Image-Guided Bio-Molecular Interventions Research and Division of Interventional Radiology, Department of Radiology, University of Washington School of Medicine, 850 Republican St, S470, Seattle, WA 98109 (J.J., Q.W., F.Z., F.X., Y.J., J.S., J.G., M.C., Q.L., D.S., X.Y.); Key Laboratory of Imaging Diagnosis and Minimally Invasive Interventional Research of Zhejiang Province, Department of Radiology, Zhejiang University Lishui Hospital, Lishui, Zhejiang, China (J.J., Q.W., J.H., J.S., M.C., Q.L.); and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China (Y.J., X.Y.).ORCID 0000-0002-2026-8755
Jun GaoFrom the Image-Guided Bio-Molecular Interventions Research and Division of Interventional Radiology, Department of Radiology, University of Washington School of Medicine, 850 Republican St, S470, Seattle, WA 98109 (J.J., Q.W., F.Z., F.X., Y.J., J.S., J.G., M.C., Q.L., D.S., X.Y.); Key Laboratory of Imaging Diagnosis and Minimally Invasive Interventional Research of Zhejiang Province, Department of Radiology, Zhejiang University Lishui Hospital, Lishui, Zhejiang, China (J.J., Q.W., J.H., J.S., M.C., Q.L.); and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China (Y.J., X.Y.).
Minjiang ChenFrom the Image-Guided Bio-Molecular Interventions Research and Division of Interventional Radiology, Department of Radiology, University of Washington School of Medicine, 850 Republican St, S470, Seattle, WA 98109 (J.J., Q.W., F.Z., F.X., Y.J., J.S., J.G., M.C., Q.L., D.S., X.Y.); Key Laboratory of Imaging Diagnosis and Minimally Invasive Interventional Research of Zhejiang Province, Department of Radiology, Zhejiang University Lishui Hospital, Lishui, Zhejiang, China (J.J., Q.W., J.H., J.S., M.C., Q.L.); and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China (Y.J., X.Y.).
Qiang LiFrom the Image-Guided Bio-Molecular Interventions Research and Division of Interventional Radiology, Department of Radiology, University of Washington School of Medicine, 850 Republican St, S470, Seattle, WA 98109 (J.J., Q.W., F.Z., F.X., Y.J., J.S., J.G., M.C., Q.L., D.S., X.Y.); Key Laboratory of Imaging Diagnosis and Minimally Invasive Interventional Research of Zhejiang Province, Department of Radiology, Zhejiang University Lishui Hospital, Lishui, Zhejiang, China (J.J., Q.W., J.H., J.S., M.C., Q.L.); and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China (Y.J., X.Y.).ORCID 0000-0002-8686-0890
David ShinFrom the Image-Guided Bio-Molecular Interventions Research and Division of Interventional Radiology, Department of Radiology, University of Washington School of Medicine, 850 Republican St, S470, Seattle, WA 98109 (J.J., Q.W., F.Z., F.X., Y.J., J.S., J.G., M.C., Q.L., D.S., X.Y.); Key Laboratory of Imaging Diagnosis and Minimally Invasive Interventional Research of Zhejiang Province, Department of Radiology, Zhejiang University Lishui Hospital, Lishui, Zhejiang, China (J.J., Q.W., J.H., J.S., M.C., Q.L.); and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China (Y.J., X.Y.).
Xiaoming YangFrom the Image-Guided Bio-Molecular Interventions Research and Division of Interventional Radiology, Department of Radiology, University of Washington School of Medicine, 850 Republican St, S470, Seattle, WA 98109 (J.J., Q.W., F.Z., F.X., Y.J., J.S., J.G., M.C., Q.L., D.S., X.Y.); Key Laboratory of Imaging Diagnosis and Minimally Invasive Interventional Research of Zhejiang Province, Department of Radiology, Zhejiang University Lishui Hospital, Lishui, Zhejiang, China (J.J., Q.W., J.H., J.S., M.C., Q.L.); and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China (Y.J., X.Y.).ORCID 0000-0002-4076-3569
University of Washington · USLishui University · CN

Funding

Intrabiliary MR/RF-enhanced chemotherapy of malignant biliary obstructionsR01EB012467 · NIBIB · UNIVERSITY OF WASHINGTON · PI YANG, XIAOMING · 2011 to 2015
$5.6M
Development of a 3D multi-modal perfusion-thermal electrode systemR01EB028095 · NIBIB · UNIVERSITY OF WASHINGTON · PI YANG, XIAOMING · 2019 to 2022
$2.4M
NIBIB NIH HHS R01 EB012467NIBIB NIH HHS R01 EB028095
6 · The paper itself

Abstract

Purpose To validate the feasibility and efficacy of intratumoral radiofrequency hyperthermia (RFH)-enhanced herpes simplex virus (HSV) thymidine kinase (TK) and ganciclovir (GCV) (hereafter, HSV-TK/GCV) gene therapy for non-small-cell lung cancer (NSCLC). Materials and Methods This study was performed from November 11, 2015, to April 14, 2017, and included (a) in vitro experiments with human NSCLC cells to establish the proof of principle, (b) in vivo experiments using mice with subcutaneous NSCLC to further demonstrate the principle, and (c) in vivo experiments using rats with orthotopic NSCLC to validate the technical feasibility. Cells, nude mice, and nude rats were randomly divided into four groups (six animals per group): (a) combination therapy (HSV-TK/GCV combined with RFH), (b) RFH, (c) HSV-TK/GCV, and (d) phosphate-buffered saline. Data were analyzed by using the Dunnett t test or Kruskal-Wallis test. Results For in vitro experiments, the cell proliferation assay showed significantly diminished viable cells with combination therapy (mean, 0.56; 95% confidence interval [CI]: 0.44, 0.68) versus RFH (mean, 0.89; 95% CI: 0.82, 0.97), HSV-TK/GCV (mean, 0.71; 95% CI: 0.56, 0.86), and phosphate-buffered saline (mean, 1; 95% CI: 1, 1) (P < .05 for all). For in vivo experiments, optical imaging showed significantly decreased relative bioluminescence signal with combination therapy (mean, 0.71 [95% CI: 0.03, 1.39] in mice; 1.29 [95% CI: 0.51, 2.06] in rats) compared with RFH (mean, 2.66 [95% CI: 1.73, 3.59] in mice; 2.26 [95% CI: 1.51, 3.01] in rats), HSV-TK/GCV (mean, 1.37 [95% CI: 0.65, 2.08] in mice; 1.76 [95% CI: 1.20, 2.31] in rats), and phosphate-buffered saline (mean, 3.07 [95% CI: 2.50, 3.65] in mice; 2.94 [95% CI: 2.29, 3.58] in rats) (P < .001 for all). US showed that the smallest relative tumor volumes occurred with combination therapy (mean, 0.60; 95% CI: 0.15, 1.05) versus RFH (mean, 2.43; 95% CI: 1.80, 3.06), HSV-TK/GCV (mean, 1.32; 95% CI: 0.75, 1.89), and phosphate-buffered saline (mean, 2.56; 95% CI: 1.75, 3.38) (P < .05 for all) in the mouse subcutaneous model. Conclusion Intratumoral radiofrequency hyperthermia-enhanced herpes simplex virus thymidine kinase and ganciclovir gene therapy for non-small-cell lung cancer is feasible and can be guided by molecular imaging. © RSNA, 2018.

Indexed as

AnimalsAntiviral AgentsCarcinoma, Non-Small-Cell LungFeasibility StudiesFemaleGanciclovirGenetic TherapyHumansHyperthermia, InducedIn Vitro TechniquesLung NeoplasmsMiceMice, NudeMolecular ImagingRatsRats, NudeAntiviral AgentsGanciclovirThymidine Kinase

Identifiers

PMID29893649
PMCPMC6067818
OpenAlexW2808362567

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.