Evidence map›Paper›PMID 29893643›Full record

ArticleRadiology2018

Regional Cerebral Blood Flow in Children and Young Adults with Chronic Kidney Disease.

Hua-Shan Liu, Erum A Hartung, Abbas F Jawad, Jeffrey B Ware, Nina Laney, Allison M Port, Ruben C Gur, Stephen R Hooper, Jerilynn Radcliffe, Susan L Furth and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Cerebral Blood Flow and Cognition in CKD: A Physiological Paradox.Journal of the American Society of Nephrology : JASN · 2025
    Article
  6. Cognitive impairment in chronic kidney disease: role of brain imaging, functional imaging, electroencephalography, cerebrospinal fluid biomarkers and sensors.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
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  17. Article
  18. Emotional and cognitive changes in chronic kidney disease.The Korean journal of internal medicine · 2022
    Review
  19. Review
  20. Cerebral Blood Flow in Chronic Kidney Disease.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Hua-Shan LiuFrom the School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan; Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa; International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan; Research Center of Translational Imaging, College of Medicine, Taipei Medical University, Taipei, Taiwan (H.S.L.); Division of Nephrology, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (E.A.H.); Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (A.F.J.); Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (J.B.W.); Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia, Pa (N.L.); Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pa (A.M.P.); Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pa (R.C.G.); Department of Allied Health Sciences, University of North Carolina School of Medicine, Chapel Hill, NC (S.R.H.); Division of Developmental and Behavioral Pediatrics, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (J.R.); Division of Nephrology, Departments of Pediatrics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania; Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia, Pa (S.L.F.); and Departments of Neurology and Radiology, Perelman School of Medicine at the University of Pennsylvania, 3W Gates Pavilion, 3400 Spruce St, Philadelphia, PA 19104 (J.A.D.).ORCID 0000-0003-4453-746X
Erum A HartungFrom the School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan; Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa; International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan; Research Center of Translational Imaging, College of Medicine, Taipei Medical University, Taipei, Taiwan (H.S.L.); Division of Nephrology, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (E.A.H.); Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (A.F.J.); Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (J.B.W.); Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia, Pa (N.L.); Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pa (A.M.P.); Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pa (R.C.G.); Department of Allied Health Sciences, University of North Carolina School of Medicine, Chapel Hill, NC (S.R.H.); Division of Developmental and Behavioral Pediatrics, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (J.R.); Division of Nephrology, Departments of Pediatrics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania; Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia, Pa (S.L.F.); and Departments of Neurology and Radiology, Perelman School of Medicine at the University of Pennsylvania, 3W Gates Pavilion, 3400 Spruce St, Philadelphia, PA 19104 (J.A.D.).
Abbas F JawadFrom the School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan; Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa; International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan; Research Center of Translational Imaging, College of Medicine, Taipei Medical University, Taipei, Taiwan (H.S.L.); Division of Nephrology, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (E.A.H.); Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (A.F.J.); Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (J.B.W.); Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia, Pa (N.L.); Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pa (A.M.P.); Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pa (R.C.G.); Department of Allied Health Sciences, University of North Carolina School of Medicine, Chapel Hill, NC (S.R.H.); Division of Developmental and Behavioral Pediatrics, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (J.R.); Division of Nephrology, Departments of Pediatrics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania; Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia, Pa (S.L.F.); and Departments of Neurology and Radiology, Perelman School of Medicine at the University of Pennsylvania, 3W Gates Pavilion, 3400 Spruce St, Philadelphia, PA 19104 (J.A.D.).
Jeffrey B WareFrom the School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan; Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa; International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan; Research Center of Translational Imaging, College of Medicine, Taipei Medical University, Taipei, Taiwan (H.S.L.); Division of Nephrology, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (E.A.H.); Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (A.F.J.); Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (J.B.W.); Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia, Pa (N.L.); Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pa (A.M.P.); Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pa (R.C.G.); Department of Allied Health Sciences, University of North Carolina School of Medicine, Chapel Hill, NC (S.R.H.); Division of Developmental and Behavioral Pediatrics, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (J.R.); Division of Nephrology, Departments of Pediatrics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania; Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia, Pa (S.L.F.); and Departments of Neurology and Radiology, Perelman School of Medicine at the University of Pennsylvania, 3W Gates Pavilion, 3400 Spruce St, Philadelphia, PA 19104 (J.A.D.).
Nina LaneyFrom the School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan; Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa; International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan; Research Center of Translational Imaging, College of Medicine, Taipei Medical University, Taipei, Taiwan (H.S.L.); Division of Nephrology, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (E.A.H.); Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (A.F.J.); Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (J.B.W.); Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia, Pa (N.L.); Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pa (A.M.P.); Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pa (R.C.G.); Department of Allied Health Sciences, University of North Carolina School of Medicine, Chapel Hill, NC (S.R.H.); Division of Developmental and Behavioral Pediatrics, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (J.R.); Division of Nephrology, Departments of Pediatrics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania; Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia, Pa (S.L.F.); and Departments of Neurology and Radiology, Perelman School of Medicine at the University of Pennsylvania, 3W Gates Pavilion, 3400 Spruce St, Philadelphia, PA 19104 (J.A.D.).
Allison M PortFrom the School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan; Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa; International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan; Research Center of Translational Imaging, College of Medicine, Taipei Medical University, Taipei, Taiwan (H.S.L.); Division of Nephrology, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (E.A.H.); Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (A.F.J.); Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (J.B.W.); Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia, Pa (N.L.); Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pa (A.M.P.); Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pa (R.C.G.); Department of Allied Health Sciences, University of North Carolina School of Medicine, Chapel Hill, NC (S.R.H.); Division of Developmental and Behavioral Pediatrics, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (J.R.); Division of Nephrology, Departments of Pediatrics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania; Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia, Pa (S.L.F.); and Departments of Neurology and Radiology, Perelman School of Medicine at the University of Pennsylvania, 3W Gates Pavilion, 3400 Spruce St, Philadelphia, PA 19104 (J.A.D.).
Ruben C GurFrom the School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan; Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa; International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan; Research Center of Translational Imaging, College of Medicine, Taipei Medical University, Taipei, Taiwan (H.S.L.); Division of Nephrology, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (E.A.H.); Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (A.F.J.); Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (J.B.W.); Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia, Pa (N.L.); Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pa (A.M.P.); Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pa (R.C.G.); Department of Allied Health Sciences, University of North Carolina School of Medicine, Chapel Hill, NC (S.R.H.); Division of Developmental and Behavioral Pediatrics, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (J.R.); Division of Nephrology, Departments of Pediatrics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania; Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia, Pa (S.L.F.); and Departments of Neurology and Radiology, Perelman School of Medicine at the University of Pennsylvania, 3W Gates Pavilion, 3400 Spruce St, Philadelphia, PA 19104 (J.A.D.).
Stephen R HooperFrom the School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan; Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa; International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan; Research Center of Translational Imaging, College of Medicine, Taipei Medical University, Taipei, Taiwan (H.S.L.); Division of Nephrology, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (E.A.H.); Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (A.F.J.); Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (J.B.W.); Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia, Pa (N.L.); Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pa (A.M.P.); Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pa (R.C.G.); Department of Allied Health Sciences, University of North Carolina School of Medicine, Chapel Hill, NC (S.R.H.); Division of Developmental and Behavioral Pediatrics, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (J.R.); Division of Nephrology, Departments of Pediatrics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania; Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia, Pa (S.L.F.); and Departments of Neurology and Radiology, Perelman School of Medicine at the University of Pennsylvania, 3W Gates Pavilion, 3400 Spruce St, Philadelphia, PA 19104 (J.A.D.).
Jerilynn RadcliffeFrom the School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan; Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa; International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan; Research Center of Translational Imaging, College of Medicine, Taipei Medical University, Taipei, Taiwan (H.S.L.); Division of Nephrology, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (E.A.H.); Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (A.F.J.); Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (J.B.W.); Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia, Pa (N.L.); Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pa (A.M.P.); Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pa (R.C.G.); Department of Allied Health Sciences, University of North Carolina School of Medicine, Chapel Hill, NC (S.R.H.); Division of Developmental and Behavioral Pediatrics, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (J.R.); Division of Nephrology, Departments of Pediatrics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania; Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia, Pa (S.L.F.); and Departments of Neurology and Radiology, Perelman School of Medicine at the University of Pennsylvania, 3W Gates Pavilion, 3400 Spruce St, Philadelphia, PA 19104 (J.A.D.).
Susan L FurthFrom the School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan; Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa; International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan; Research Center of Translational Imaging, College of Medicine, Taipei Medical University, Taipei, Taiwan (H.S.L.); Division of Nephrology, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (E.A.H.); Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (A.F.J.); Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (J.B.W.); Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia, Pa (N.L.); Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pa (A.M.P.); Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pa (R.C.G.); Department of Allied Health Sciences, University of North Carolina School of Medicine, Chapel Hill, NC (S.R.H.); Division of Developmental and Behavioral Pediatrics, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (J.R.); Division of Nephrology, Departments of Pediatrics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania; Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia, Pa (S.L.F.); and Departments of Neurology and Radiology, Perelman School of Medicine at the University of Pennsylvania, 3W Gates Pavilion, 3400 Spruce St, Philadelphia, PA 19104 (J.A.D.).
John A DetreFrom the School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan; Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa; International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan; Research Center of Translational Imaging, College of Medicine, Taipei Medical University, Taipei, Taiwan (H.S.L.); Division of Nephrology, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (E.A.H.); Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (A.F.J.); Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (J.B.W.); Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia, Pa (N.L.); Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pa (A.M.P.); Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pa (R.C.G.); Department of Allied Health Sciences, University of North Carolina School of Medicine, Chapel Hill, NC (S.R.H.); Division of Developmental and Behavioral Pediatrics, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (J.R.); Division of Nephrology, Departments of Pediatrics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania; Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia, Pa (S.L.F.); and Departments of Neurology and Radiology, Perelman School of Medicine at the University of Pennsylvania, 3W Gates Pavilion, 3400 Spruce St, Philadelphia, PA 19104 (J.A.D.).
Taipei Medical University Hospital · TWChildren's Hospital of Philadelphia · USUniversity of North Carolina at Chapel Hill · US

Funding

INSTITUTIONAL CLINICAL AND TRANSLATIONAL SCIENCE AWARDUL1RR024134 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2006 to 2011
$70.4M
Institutional Clinical and Translational Science AwardUL1TR000003 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2012 to 2015
$38.9M
Training and DisseminationP41EB015893 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI DETRE, JOHN A · 2012 to 2019
$11.3M
Perfusion MRI for Multi-site Studies of Brain FunctionR01MH080729 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI ALSOP, DAVID CHARLES, DETRE, JOHN A · 2007 to 2017
$3.8M
Novel Imaging Biomarkers in Autosomal Recessive Polycystic Kidney DiseaseK23DK109203 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI HARTUNG, ERUM AFTAB · 2016 to 2019
$728k
NCATS NIH HHS UL1 TR000003NCRR NIH HHS UL1 RR024134NIBIB NIH HHS P41 EB015893NIDDK NIH HHS K23 DK109203NIMH NIH HHS R01 MH080729
6 · The paper itself

Abstract

Purpose To investigate the pathophysiologic effects of chronic kidney disease (CKD) on brain function in children with CKD by correlating cerebral blood flow (CBF) with clinical and behavioral indexes. Materials and Methods In this prospective study, 73 pediatric patients with CKD (mean age, 15.80 years ± 3.63; range, 9-25 years) and 57 control subjects (mean age, 15.65 years ± 3.76; range, 9-25 years) were recruited. CBF measurements were acquired with an MRI arterial spin labeling scheme. Neurocognitive measurements were performed with traditional and computerized neurocognitive batteries. Clinical data were also collected. Group-level global and regional CBF differences between patients with CKD and control subjects were assessed. Regression analyses were conducted to evaluate the associations among regional CBF, clinical variables, and cognitive performance. Results Patients with CKD showed higher global CBF compared with control subjects that was attributable to reduced hematocrit level (mean, 60.2 mL/100 g/min ± 9.0 vs 56.5 mL/100 g/min ± 8.0, respectively). White matter CBF showed correlation with blood pressure (r = 0.244, P = .039), a finding suggestive of altered cerebrovascular autoregulation. Regional CBF differences between patients and control subjects included regions in the "default mode" network. In patients with CKD, positive extrema in the precuneus showed a strong correlation with executive function (ρ = 0.608, P = .001). Conclusion Systemic effects of estimated glomerular filtration rate, hematocrit level, and blood pressure on CBF and alterations in regional CBF may reflect impaired brain function underlying neurocognitive symptoms in CKD. These findings further characterize the nature of alterations in brain physiologic features in children, adolescents, and young adults with CKD.

Indexed as

AdolescentAdultBrainCerebrovascular CirculationChildFemaleHumansMagnetic Resonance ImagingMaleProspective StudiesRenal Insufficiency, ChronicSpin LabelsYoung AdultSpin Labels

Identifiers

PMID29893643
PMCPMC6102080
OpenAlexW2808459199

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