Evidence map›Paper›PMID 29893472›Full record

ArticleBJOG : an international journal of obstetrics and gynaecology2018

Portable Pocket colposcopy performs comparably to standard-of-care clinical colposcopy using acetic acid and Lugol's iodine as contrast mediators: an investigational study in Peru.

J L Mueller, C T Lam, D Dahl, M N Asiedu, M S Krieger, Y Bellido-Fuentes, M Kellish, J Peters, A Erkanli, E J Ortiz and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BJOG : an international journal of obstetrics and gynaecology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 3 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. A systematic review of handheld tools in lieu of colposcopy for cervical neoplasia and female genital schistosomiasis.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2021
    Pooled it
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  14. Optical imaging technologies forCurrent opinion in biomedical engineering · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

J L MuellerDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
C T LamDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
D DahlDuke Global Health Institute, Duke University, Durham, NC, USA.
M N AsieduDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
M S KriegerDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Y Bellido-FuentesLiga Contra el Cáncer, Pueblo Libre, Lima, Peru.
M KellishDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
J PetersDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
A ErkanliDepartment of Biostatistics and Bioinformatics, Duke University Medical School, Durham, NC, USA.
E J OrtizDuke Global Health Institute, Duke University, Durham, NC, USA.
L C MuasherDepartment of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA.
P T TaylorDepartment of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA.
J W SchmittDuke Global Health Institute, Duke University, Durham, NC, USA.
G VenegasLiga Contra el Cáncer, Pueblo Libre, Lima, Peru.
N RamanujamDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Duke University · USDuke Institute for Health Innovation · USDuke Medical Center · USLiga Contra el Cancer · PE

Funding

Culturally appropriate screening and diagnosis of cervical cancer in East AfricaR01CA193380 · NCI · DUKE UNIVERSITY · PI RAMANUJAM, NIRMALA · 2015 to 2019
$2.9M
A Viable Solution for a See and Treat Paradigm for Cervical Pre-cancer in AfricaR01CA195500 · NCI · DUKE UNIVERSITY · PI RAMANUJAM, NIRMALA · 2015 to 2017
$647k
NCI NIH HHS R01 CA193380NCI NIH HHS R01 CA195500
6 · The paper itself

Abstract

objectiveOur goal was to develop a tele-colposcopy platform for primary-care clinics to improve screening sensitivity and access. Specifically, we developed a low-cost, portable Pocket colposcope and evaluated its performance in a tertiary healthcare centre in Peru. DESIGN AND

settingImages of the cervix were captured with a standard-of-care and Pocket colposcope at la Liga Contra el Cáncer in Lima, Peru. POPULATION: Two hundred Peruvian women with abnormal cytology and/or human papillomavirus positivity were enrolled.

methodsImages were collected using acetic acid and Lugol's iodine as contrast agents. Biopsies were taken as per standard-of-care procedures.

main outcome measuresAfter passing quality review, images from 129 women were sent to four physicians who provided a diagnosis for each image.

resultsPhysician interpretation of images from the two colposcopes agreed 83.1% of the time. The average sensitivity and specificity of physician interpretation compared with pathology was similar for the Pocket (sensitivity = 71.2%, specificity = 57.5%) and standard-of-care (sensitivity = 79.8%, specificity = 56.6%) colposcopes. When compared with a previous study where only acetic acid was applied to the cervix, results indicated that adding Lugol's iodine as a secondary contrast agent improved the percent agreement between colposcopes for all pathological categories by up to 8.9% and the sensitivity and specificity of physician interpretation compared with pathology by over 6.0 and 9.0%, respectively.

conclusionsThe Pocket colposcope performance was similar to that of a standard-of-care colposcope when used to identify precancerous and cancerous lesions using acetic acid and Lugol's iodine during colposcopy examinations in Peru. TWEETABLE ABSTRACT: The Pocket colposcope performance was similar to that of a standard-of-care colposcope when identifying cervical lesions.

Indexed as

ColposcopesColposcopyAcetic AcidAdultBiopsyContrast MediaEarly Detection of CancerEquipment DesignFemaleHumansImage EnhancementIodidesMiddle AgedPeruPoint-of-Care SystemsPrimary Health CareAcetic AcidContrast MediaIodidesLugol's solutionBiomedicalcervical cancerdiagnostic imagingprimary health caresquamous intraepithelial lesions of the cervixtechnologyuterine cervical diseases

Identifiers

PMID29893472
PMCPMC6115285
OpenAlexW2807878251

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.