ReviewAngewandte Chemie (International ed. in English)2019
Polyoxometalates as Potential Next-Generation Metallodrugs in the Combat Against Cancer.
Review in Angewandte Chemie (International ed. in English), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
122 citing papers in PubMed.
- Keggin-Type Polyoxometalates as a Systematic Antiviral Scaffold: Activity, Cytotoxicity, and Solution Stability across Heteroion and Addenda Metal Variations.Journal of medicinal chemistry · 2026Article
- The Phosphate-Bridged Pentapalladium(II)-Containing 18-Tungsto-4-Phosphate [PdInorganic chemistry · 2026Article
- Potential Activity of Non-Platinum Metal-Based Organic Complexes Against Different Cancer Cell Types.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Peroxo-Containing Heteropolyanions [{XWInorganic chemistry · 2026Article
- More Than a Buffer in Biochemistry: Tris as an Architect and Gatekeeper of Metal-Oxo Assembly.Angewandte Chemie (International ed. in English) · 2026Article
- Polyoxometalates in environmental remediation and energy storage.Environmental science. Nano · 2026Review
- Recent Advances in Polyoxometalates Targeting Proteins Associated with Alzheimer's Disease: From Molecular Mechanisms to Therapeutic Applications.International journal of molecular sciences · 2026Review
- Dawson- and Lindqvist-Type Hybrid Polyoxometalates: Synthesis, Characterization and CaMolecules (Basel, Switzerland) · 2025Article
- Active Learning-Assisted Exploration of [POAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Bioactivity of Decavanadate Compounds: Can TheirInorganic chemistry · 2025Article
- Data-Driven Polyoxometalate Chemistry.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Uncovering Polyoxometalate Speciation in Hydrothermal Systems by Combining Computational Simulation with X-ray Total Scattering.Journal of the American Chemical Society · 2025Article
- Delineating the Effects of Counterions on the Structural and Vibrational Properties of U(IV) Lindqvist Polyoxometalate Complexes.Inorganic chemistry · 2025Article
- Biomimetic Hierarchical Construction of Anti-Tumor Polyoxopalladates for Cancer Therapy.Angewandte Chemie (International ed. in English) · 2025Article
- Self-Assembly Engineering of Fullerene-Like Polyhedra: VAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Donor and Geometry Optimization: Fresh Perspectives for the Design of Polyoxometalate Charge Transfer Chromophores.Inorganic chemistry · 2025Article
- Interactions of Laurylated and Myristoylated KR12 Fragment of the LL37 Peptide with Polyoxidovanadates.Molecules (Basel, Switzerland) · 2025Article
- Donut-shaped [NaPJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2025Article
- Exploring New Bioorthogonal Catalysts: Scaffold Diversity in Catalysis for Chemical Biology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Nanosponge-Encapsulated Polyoxometalates: Unveiling the Multi-Faceted Potential Against Cancers and Metastases Through Comprehensive Preparation, Characterization, and Computational Exploration.Pharmaceuticals (Basel, Switzerland) · 2025Article
62 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Polyoxometalates (POMs) are an emerging class of inorganic metal oxides, which over the last decades demonstrated promising biological activities by the virtue of their great diversity in structures and properties. They possess high potential for the inhibition of various tumor types; however, their unspecific interactions with biomolecules and toxicity impede their clinical usage. The current focus of the field of biologically active POMs lies on organically functionalized and POM-based nanocomposite structures as these hybrids show enhanced anticancer activity and significantly reduced toxicity towards normal cells in comparison to unmodified POMs. Although the antitumor activity of POMs is well documented, their mechanisms of action are still not well understood. In this Review, an overview is given of the cytotoxic effects of POMs with a special focus on POM-based hybrid and nanocomposite structures. Furthermore, we aim to provide proposed mode of actions and to identify molecular targets. POMs are expected to develop into the next generation of anticancer drugs that selectively target cancer cells while sparing healthy cells.
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