Evidence map›Paper›PMID 29893430›Full record

ArticleHistopathology2018

T-cell receptor-δ expression and γδ+ T-cell infiltrates in primary cutaneous γδ T-cell lymphoma and other cutaneous T-cell lymphoproliferative disorders.

Melissa Pulitzer, Shamir Geller, Erica Kumar, Denise Frosina, Alison Moskowitz, Steven Horwitz, Patricia Myskowski, Meenal Kheterpal, Alexander Chan, Ahmet Dogan and 1 more

Open access · greenAbstract read
In one paragraph

Article in Histopathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Melissa PulitzerDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-0606-9186
Shamir GellerDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Erica KumarDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Denise FrosinaDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Alison MoskowitzDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Steven HorwitzDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Patricia MyskowskiDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Meenal KheterpalDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Alexander ChanDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Ahmet DoganDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Achim JungbluthDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Memorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748NIH/NCI Cancer Center P30 CA008748
6 · The paper itself

Abstract

aimsThe diagnosis of cutaneous γδ T-cell lymphoma (GDTCL) requires the identification of γδ chains of the T-cell receptor (TCR). Our aim in this study was, by using a new monoclonal antibody (mAb) against TCRδ, to evaluate TCRδ expression in formalin-fixed paraffin-embedded (FFPE) skin tissue from TCRγ+ cutaneous T-cell lymphoma (CTCL), and to assess TCRδ expression within a spectrum of other cutaneous lymphoproliferative disorders (CLPDs). METHODS AND

resultsTwelve cases (10 patients) with TCRγ+ CTCL and 132 additional CLPD cases (127 patients) were examined, including mycosis fungoides (MF) (n = 60), cutaneous GDTCL (n = 15), subcutaneous panniculitis-like T-cell lymphoma (SPTCL) (n = 11), and CD30

conclusionsmAb H-41 against TCRδ matches TCRγ in immunostaining FFPE tissues from GDTCL, supporting H-41 as a replacement for mAb γ3.20. TCRδ expression in our study suggests that the true occurrence of γδ+ non-GDTCL CTCL/CLPD may be lower than suggested by the recent literature.

Indexed as

Antibodies, MonoclonalAdultFemaleHumansImmunohistochemistryLymphoma, T-Cell, CutaneousLymphoproliferative DisordersMaleReceptors, Antigen, T-Cell, gamma-deltaSkin NeoplasmsAntibodies, MonoclonalReceptors, Antigen, T-Cell, gamma-deltaclassificationimmunohistochemistryimmunological techniqueslymphoproliferative disordersT-cell lymphoma

Identifiers

PMID29893430
PMCPMC6153041
OpenAlexW2807802402

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.