Evidence map›Paper›PMID 29893028›Full record

ArticleInternational journal of experimental pathology2018

Leptin and Leptin receptor polymorphisms, plasma Leptin levels and obesity in Tunisian volunteers.

Zayani Nesrine, Hamdouni Haithem, Boumaiza Imen, Neffati Fadoua, Omezzine Asma, Najjar Mohamed Fadhel, Bouslama Ali

Open access · greenAbstract read
In one paragraph

Article in International journal of experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 5 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 5 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Pooled it
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  6. Article
  7. Review
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  10. Article
  11. Article
  12. Role of Leu72Met ofNutrients · 2022
    Article
  13. Review
  14. Article
  15. Impaired Leptin Signalling in Obesity: Is Leptin a New Thermolipokine?International journal of molecular sciences · 2021
    Review
  16. Article
  17. Leptin Receptor Compound Heterozygosity in Humans and Animal Models.International journal of molecular sciences · 2021
    Review
  18. Leptin and Obesity: Role and Clinical Implication.Frontiers in endocrinology · 2021
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Zayani NesrineBiochemistry Department, LR12SP11, Sahloul University Hospital, Sousse, Tunisia.ORCID 0000-0002-5610-1068
Hamdouni HaithemBiochemistry Department, LR12SP11, Sahloul University Hospital, Sousse, Tunisia.
Boumaiza ImenBiochemistry Department, LR12SP11, Sahloul University Hospital, Sousse, Tunisia.
Neffati FadouaLaboratory of Biochemistry and Toxicology, Monastir's University Hospital, Monastir, Tunisia.
Omezzine AsmaBiochemistry Department, LR12SP11, Sahloul University Hospital, Sousse, Tunisia.
Najjar Mohamed FadhelLaboratory of Biochemistry and Toxicology, Monastir's University Hospital, Monastir, Tunisia.
Bouslama AliBiochemistry Department, LR12SP11, Sahloul University Hospital, Sousse, Tunisia.
Hôpital Sahloul · TNUniversity of Monastir · TN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adipose tissue is an important endocrine organ that secretes a number of adipokines, like Leptin (LEP). The aim this study was to investigate the prevalence of single nucleotide polymorphisms in LEP gene (LEP 3'UTR A/C, -2548 G/A) and LEPR (K109R and Q223R) and their association with Leptin level and obesity. We recruited 169 non-obese (body mass index [BMI] = 24.51-3.69 kg/m

Indexed as

Polymorphism, Single NucleotideAdultCase-Control StudiesFemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseHaplotypesHumansLeptinMaleMiddle AgedObesityPhenotypeReceptors, LeptinRisk FactorsLEP protein, humanLEPR protein, humanLeptinReceptors, LeptinLEPLEPRLeptin levelsobesityTunisian volunteers

Identifiers

PMID29893028
PMCPMC6104422
OpenAlexW2808557236

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.