ArticleJournal of clinical hypertension (Greenwich, Conn.)2018
Joint interaction effect of metabolic syndrome and obstructive sleep apnea on hypertension.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Association of Metabolic Score for Insulin Resistance With Resistant Hypertension and Hypertension in Obstructive Sleep Apnea.The clinical respiratory journal · 2026Article
- Altered Lipid Profile Is a Risk Factor for the Poor Progression of COVID-19: From Two Retrospective Cohorts.Frontiers in cellular and infection microbiology · 2021Article
- Fasting blood glucose level and hypertension risk in aging benign prostatic hyperplasia patients.Aging · 2019Observational
- Autonomic nervous system might be related with circadian rhythms and have the intricate effects in obstructive sleep apnea with metabolic syndrome.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- Circadian rhythms might be the key joint role in intricate effects among metabolic syndrome, obstructive sleep apnea, and hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- Joint interaction effect of metabolic syndrome and obstructive sleep apnea on hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
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7 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Numerous studies have observed a relationship between obstructive sleep apnea and hypertension, but the effects of metabolic syndrome on hypertension, and their interaction with obstructive sleep apnea, remain unclear. For this study, a total of 2972 patients were recruited from the Shanghai Sleep Health Study. Data from overnight polysomnography parameters, serum lipids, fasting blood glucose, blood pressure, and anthropometric measurements were collected. The authors then explored the independent associations and multiplicative and additive interactions of predictors of metabolic syndrome with hypertension. A positive dose-response relationship was observed between systolic blood pressure and diastolic blood pressure and quartiles of fasting glucose, triglyceride, low-density lipoprotein cholesterol, body mass index, and apnea-hypopnea index. Furthermore, logistic regression analysis showed that, in men, a high triglyceride level, hyperglycemia, and overweight status (and their interaction effect on obstructive sleep apnea) were associated with hypertension. Being overweight and hyperglycemic may markedly augment the adverse effect of obstructive sleep apnea on hypertension in men. Therefore, hypertension therapy should be individualized based on the specific comorbidities of each patient.
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