ReviewMethods in molecular biology (Clifton, N.J.)2018
The Deiodinase Trio and Thyroid Hormone Signaling.
Review in Methods in molecular biology (Clifton, N.J.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Associations of selenium status with all-cause and cause-specific mortality: a systematic review and meta-analysis of cohort studies.Redox biology · 2025Pooled it
- Thyroid disorders in patients with human immunodeficiency virus infection: a meta-analysis.AIDS research and therapy · 2025Pooled it
- Trial
- Association Between Chronic Kidney Disease and Subclinical Hypothyroidism Categorized by Hypertension Status.Diseases (Basel, Switzerland) · 2026Article
- Selenoproteins: Minute yet vital players governing cellular fate.Genes & diseases · 2026Review
- Longitudinal Changes in Thyroid Hormones and Serum Albumin Following CABG, AVR, and PCI: An Exploratory Electronic Medical Record Study.Medical sciences (Basel, Switzerland) · 2026Article
- Convergent thyroid-ATPase interactions regulate collective behavior in Danionella.Cell reports · 2026Article
- Thyroid-Microbiome Allostasis and Mitochondrial Performance: An Integrative Perspective in Exercise Physiology.Nutrients · 2025Review
- Pathogenic MCT8V235L creates a steric clash that is alleviated by a compensating mutation of MCT8F285A.European thyroid journal · 2025Article
- Thyroid Hormones and Metabolism Regulation: Which Role on Brown Adipose Tissue and Browning Process?Biomolecules · 2025Review
- High TSH levels during TSH suppression therapy in DTC postoperative patients are associated with low DIO2 expression in the thyroid and impaired thyroid hormone sensitivity.Frontiers in endocrinology · 2025Article
- Effect of Empagliflozin on Serum Levels of Thyroid Hormones Among Prediabetic and Diabetic Patients.International journal of endocrinology · 2025Article
- Effect of enhanced plane of nutrition in early life on the transcriptome and proteome of the anterior pituitary gland in Angus heifer calves.BMC genomics · 2024Article
- Molecular basis of urostyle development in frogs: genes and gene regulation underlying an evolutionary novelty.Open biology · 2024Article
- Article
- The global burden, trends, and inequalities of individuals with developmental and intellectual disabilities attributable to iodine deficiency from 1990 to 2019 and its prediction up to 2030.Frontiers in nutrition · 2024Article
- Biological and Catalytic Properties of Selenoproteins.International journal of molecular sciences · 2023Review
- Environmental endocrine disruptors and amphibian immunity: A bridge between the thyroid hormone axis and T cell development.Developmental and comparative immunology · 2023Article
- Iodine Status in Pregnant Women Having Urinary Fluoride in Contaminated Areas: A Case Study of Phayao Province.Journal of environmental and public health · 2023Article
- The role of selenoproteins in neurodevelopment and neurological function: Implications in autism spectrum disorder.Frontiers in molecular neuroscience · 2023Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Thyroid hormone signaling is customized in a time and cell-specific manner by the deiodinases, homodimeric thioredoxin fold containing selenoproteins. This ensures adequate T3 action in developing tissues, healthy adults and many disease states. D2 activates thyroid hormone by converting the pro-hormone T4 to T3, the biologically active thyroid hormone. D2 expression is tightly regulated by transcriptional mechanisms triggered by endogenous as well as environmental cues. There is also an on/off switch mechanism that controls D2 activity that is triggered by catalysis and functions via D2 ubiquitination/deubiquitination. D3 terminates thyroid hormone action by inactivation of both T4 and T3 molecules. Deiodinases play a role in thyroid hormone homeostasis, development, growth and metabolic control by affecting the intracellular levels of T3 and thus gene expression on a cell-specific basis. In many cases, tight control of these pathways by T3 is achieved with coordinated reciprocal changes in D2-mediated thyroid hormone activation D3-mediated thyroid hormone inactivation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.