Evidence map›Paper›PMID 29892573›Full record

ReviewFrontiers in oncology2018

The Shifting Paradigm of Prognostic Factors of Colorectal Liver Metastases: From Tumor-Centered to Host Immune-Centered Factors.

Matteo Donadon, Ana Lleo, Luca Di Tommaso, Cristiana Soldani, Barbara Franceschini, Massimo Roncalli, Guido Torzilli

Abstract readReview
In one paragraph

Review in Frontiers in oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Matteo DonadonDepartment of Hepatobiliary and General Surgery, Humanitas Clinical and Research Center, Rozzano, Italy.
Ana LleoDepartment of Biomedical Science, Humanitas University, Rozzano, Italy.
Luca Di TommasoDepartment of Biomedical Science, Humanitas University, Rozzano, Italy.
Cristiana SoldaniDepartment of Hepatobiliary and General Surgery, Humanitas Clinical and Research Center, Rozzano, Italy.
Barbara FranceschiniDepartment of Hepatobiliary and General Surgery, Humanitas Clinical and Research Center, Rozzano, Italy.
Massimo RoncalliDepartment of Biomedical Science, Humanitas University, Rozzano, Italy.
Guido TorzilliDepartment of Hepatobiliary and General Surgery, Humanitas Clinical and Research Center, Rozzano, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The determinants of prognosis in patients with colorectal liver metastases (CLM) have been traditionally searched among the tumoral factors, either of the primary colorectal tumor or of the CLM. While many different scoring systems have been developed based on those clinic-pathological factors with disparate results, there has been the introduction of genetic biological markers that added a theranostic perspective. More recently, other important elements, such as those factors related to the host immune system, have been proposed as determinants of prognosis of CLM patients. In the present work, we review the current prognostic factors of CLM patients as well as the burgeoning shifting paradigm of prognostication that relies on the host immune system.

Indexed as

colorectal cancercolorectal cancer liver metastasescolorectal liver metastaseshost immune systemimmune responseimmunotherapy

Identifiers

PMID29892573
PMCPMC5985314

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.