Evidence map›Paper›PMID 29892571›Full record

ArticleFrontiers in oncology2018

A Testosterone Metabolite 19-Hydroxyandrostenedione Induces Neuroendocrine Trans-Differentiation of Prostate Cancer Cells

Tatjana Abaffy, James R Bain, Michael J Muehlbauer, Ivan Spasojevic, Shweta Lodha, Elisa Bruguera, Sara K O'Neal, So Young Kim, Hiroaki Matsunami

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 52 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. TRAF4-mediated nonproteolytic ubiquitination of androgen receptor promotes castration-resistant prostate cancer.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Tatjana AbaffyDepartment of Molecular Genetics and Microbiology, Duke Cancer Institute, Duke University School of Medicine, Durham, NC, United States.
James R BainDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, United States.
Michael J MuehlbauerDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, United States.
Ivan SpasojevicDepartment of Medicine, Duke University School of Medicine, Durham, NC, United States.
Shweta LodhaDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, United States.
Elisa BrugueraDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, United States.
Sara K O'NealDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, United States.
So Young KimDepartment of Molecular Genetics and Microbiology, Functional Genomics Shared Resource, Duke University School of Medicine, Durham, NC, United States.
Hiroaki MatsunamiDepartment of Molecular Genetics and Microbiology, Department of Neurobiology, Duke Institute for Brain Sciences, Duke Cancer Institute, Duke University School of Medicine, Durham, NC, United States.
Duke University · US

Funding

Peripheral Odor Coding in MammalsR01DC014423 · NIDCD · DUKE UNIVERSITY · PI MATSUNAMI, HIROAKI · 2015 to 2019
$2.3M
Biogenesis of olfactory G protein-coupled receptorsR01DC016224 · NIDCD · DUKE UNIVERSITY · PI MATSUNAMI, HIROAKI · 2017 to 2021
$2.2M
Data commons for 'omic, microscopy and analysis core facilitiesS10OD018164 · OD · DUKE UNIVERSITY · PI WRAY, GREGORY A. · 2014 to 2014
$598k
NIDCD NIH HHS R01 DC014423NIDCD NIH HHS R01 DC016224NIH HHS S10 OD018164
6 · The paper itself

Abstract

Olfactory receptor OR51E2, also known as a Prostate Specific G-Protein Receptor, is highly expressed in prostate cancer but its function is not well understood. Through

Indexed as

19-hydroxyandrostenedioneagonistsneuroendocrine trans-differentiationneuron-specific enolaseolfactory receptorOR51E2prostate cancerPSGR

Identifiers

PMID29892571
PMCPMC5985834
OpenAlexW2785562108

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.