ArticleJournal of oral biology and craniofacial research
A systematic review of biomarkers of gingival crevicular fluid: Their predictive role in diagnosis of periodontal disease status.
Article in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Biomarkers for diagnosis of stage III, grade C with molar incisor pattern periodontitis in children and young adults: a systematic review and meta-analysis.Clinical oral investigations · 2023Pooled it
- Efficacy of MMP-8 Level in Gingival Crevicular Fluid to Predict the Outcome of Nonsurgical Periodontal Treatment: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Nonsurgical Treatment of Periodontitis in Menopausal Patients: A Randomized Control Trial.BioMed research international · 2024Trial
- Multi-Omics Integration Reveals the Genetic Mechanisms of Periodontitis and Predicts Therapeutic Drugs.International dental journal · 2026Article
- Clinical Investigation of Periodontal Health in Smoker and Nonsmoker Individuals.International journal of dentistry · 2026Article
- Article
- A multi-platform analysis of human gingival crevicular fluid reveals ferroptosis as a relevant regulated cell death mechanism during the clinical progression of periodontitis.International journal of oral science · 2024Article
- The Influence of Fixed Dental Prostheses on the Expression of Inflammatory Markers and Periodontal Status-Narrative Review.Medicina (Kaunas, Lithuania) · 2023Review
- Short-Term (4 Day) Effects of Oral Rinsing with Miswak and Green Tea on Gingival Crevicular Fluid Flow and IL-1β Levels: A Pilot Study.Healthcare (Basel, Switzerland) · 2023Article
- The Effect of Non-Surgical Periodontal Therapy on Pentraxin-3 Concentration in Gingival Crevicular Fluid of Chronic Periodontitis Patients: A Clinical Trial.Journal of dentistry (Shiraz, Iran) · 2022Article
- Comparative Evaluation of Gingival Crevicular Fluid Interleukin-17, 18 and 21 in Different Stages of Periodontal Health and Disease.Medicina (Kaunas, Lithuania) · 2022Article
- Biomarkers in Oral Fluids as Diagnostic Tool for Psoriasis.Life (Basel, Switzerland) · 2022Review
- Article
- Cytokines in gingival crevicular fluid in elderly rheumatoid arthritis patients in a population-based cross-sectional study: RANTES was associated with periodontitis.Journal of periodontal research · 2021Article
- Interleukin-1β activity in gingival crevicular fluid of abutment teeth with temporary fixed restorations versus final fixed restorations: Prospective observational study.The Saudi dental journal · 2021Article
- Silencing matrix metalloproteinase-13 (Mmp-13) reduces inflammatory bone resorption associated with LPS-induced periodontal disease in vivo.Clinical oral investigations · 2021Article
- Inflammation of the periodontium associates with risk of future cardiovascular events.Journal of periodontology · 2021Article
- Biomarkers associated with periodontitis and peri-implantitis: a systematic review.Journal of periodontal & implant science · 2021Review
- Treatment of localized aggressive periodontitis alters local host immunoinflammatory profiles: A long-term evaluation.Journal of clinical periodontology · 2021Article
- Usefulness of hemoglobin examination in gingival crevicular fluid during supportive periodontal therapy to diagnose the pre-symptomatic state in periodontal disease.Clinical oral investigations · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of the study was to conduct a systematic review of the literature so as to evaluate and summarize the diagnostic and prognostic potential of GCF. Included studies were systematically analyzed based on PRISMA (Preferred Reporting Items For Systematic Reviews and Meta Analyses) and studies were identified based on the-PICO (Glossary of evidence based terms 2007): 1)Patients with chronic periodontitis.2)Intervention- NSPT (Non-SurgicalPeriodontal therapy); NSPT + Chemotherapeutics.3)Comparison between treated v/s non treated sites.4)Outcomes measured: Analysis of variation in constituents of GCF. Electronic database search of Pubmed, Medline, Google Scholar and Scopus was performed using (MeSH) terms- Gingival Crevicular fluid and Cytokines, MMP's, NE, PGE-2, A2M, B2M, ALP, AST, Osteocalcin and Calprotectin. Articles published between year 2000-2016 were reviewed and were included based on inclusion and exclusion criteria. Based on this systematic review of literature, it can be concluded that analysis of constituents of GCF can be used as an effective and efficient diagnostic tool of periodontal diseases. These biomarkers in turn with their prognostic significance could act as a valuable tool in the combat of periodontal disease.
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Registered trials
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