Evidence map›Paper›PMID 29892490›Full record

ArticleArab journal of urology2018

Comparing tamsulosin, silodosin versus silodosin plus tadalafil as medical expulsive therapy for lower ureteric stones: A randomised trial.

Md Jawaid Rahman, M Shazib Faridi, Naloh Mibang, Rajendra Sinam Singh

Registry-linked trialOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arab journal of urology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06999135 (Comparison of Silodosin and Tamsulosin for Medical Expulsive Therapy in Patients With Ureteral Stones), which is not on this map. Cited by 16 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 6 pooled it
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06999135 nacompletednot on this mapstarted 2023, after this paper: background citation

Comparison of Silodosin and Tamsulosin for Medical Expulsive Therapy in Patients With Ureteral Stones

TypeinterventionalSponsorFatima Jinnah Medical UniversityRan2023 to 2024Enrolled200ConditionsTamsulosin, Silodosin, Medical Expulsive TherapyArmsSilodosin
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 6 syntheses or guidelines pooled it, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Md Jawaid RahmanDepartment of Urology, Regional Institute of Medical Sciences, Imphal, Manipur, India.
M Shazib FaridiDepartment of Urology, Regional Institute of Medical Sciences, Imphal, Manipur, India.
Naloh MibangDepartment of Urology, Regional Institute of Medical Sciences, Imphal, Manipur, India.
Rajendra Sinam SinghDepartment of Urology, Regional Institute of Medical Sciences, Imphal, Manipur, India.
Regional Institute of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare the efficacy of tamsulosin, silodosin, and silodosin plus tadalafil as medical expulsive therapy (MET) for distal ureteric calculi.

methodsIn all, 120 patients who met the inclusion criteria were randomised into one of three treatment arms: tamsulosin (Group A), silodosin (Group B), and silodosin plus tadalafil (Group C). The drugs were given for a maximum of 4 weeks. The primary endpoint was the stone expulsion rate and secondary endpoints were stone expulsion time, number of pain episodes, and side-effects associated with MET. The follow-up period was for 4 weeks, after which ureteroscopic lithotripsy was done to remove any stones that were not expelled.

resultsThere was a statistically significantly higher stone expulsion rate in Group C (90%) as compared to groups A (57.5%) and B (77.5%) with a shorter mean time to stone expulsion. Also, there were statistically fewer pain episodes in Group C as compared to groups A and B. There were no serious side-effects.

conclusionThe present study concludes that the combination of silodosin and tadalafil increases the ureteric stone expulsion rate and decreases the expulsion time significantly. This combination provided significantly better control of pain without any serious side-effects.

Indexed as

AR, adrenergic receptorcGMP, cyclic guanosine monophosphateEfficacyKUB, kidney, ureter, and bladderMET, medical expulsive therapyPDE(-5), phosphodiesterase (type 5)SilodosinTadalafilTamsulosinUreteric calculiUSG, ultrasonography

Identifiers

PMID29892490
PMCPMC5992261
OpenAlexW2780697381

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.