Evidence map›Paper›PMID 29892372›Full record

ArticleRoyal Society open science2018

The polyphyly of

Spencer C Galen, Janus Borner, Ellen S Martinsen, Juliane Schaer, Christopher C Austin, Christopher J West, Susan L Perkins

Abstract read
In one paragraph

Article in Royal Society open science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Survey of Haemosporidian Parasites in Wild Stone-Curlews (Animals : an open access journal from MDPI · 2025
    Article
  12. Article
  13. Article
  14. Molecular Screening ofAnimals : an open access journal from MDPI · 2025
    Article
  15. Article
  16. Article
  17. Metagenomic analysis reveals extreme complexity ofmedRxiv : the preprint server for health sciences · 2025
    Article
  18. Phylogenetic assessment ofParasitology · 2025
    Article
  19. Article
  20. HiddenCurrent research in parasitology & vector-borne diseases · 2025
    Article

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Spencer C GalenSackler Institute for Comparative Genomics, American Museum of Natural History, Central Park West at 79th St., New York, NY 10024, USA.ORCID 0000-0003-0209-1535
Janus BornerInstitute of Zoology, Biocenter Grindel, University of Hamburg, Martin-Luther-King-Platz 3, D-20146 Hamburg, Germany.
Ellen S MartinsenCenter for Conservation Genomics, Smithsonian Conservation Biology Institute, National Zoological Park, PO Box 37012, MRC5503, Washington, DC 20013-7012, USA.
Juliane SchaerDepartment of Biology, Humboldt University, 10115, Berlin, Germany.
Christopher C AustinDepartment of Biological Sciences, Museum of Natural Science, Louisiana State University, Baton Rouge, LA 70803, USA.
Christopher J WestWildlife Program, Yurok Tribe, Klamath, CA 95548, USA.
Susan L PerkinsSackler Institute for Comparative Genomics, American Museum of Natural History, Central Park West at 79th St., New York, NY 10024, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The evolutionary relationships among the apicomplexan blood pathogens known as the malaria parasites (order Haemosporida), some of which infect nearly 200 million humans each year, has remained a vexing phylogenetic problem due to limitations in taxon sampling, character sampling and the extreme nucleotide base composition biases that are characteristic of this clade. Previous phylogenetic work on the malaria parasites has often lacked sufficient representation of the broad taxonomic diversity within the Haemosporida or the multi-locus sequence data needed to resolve deep evolutionary relationships, rendering our understanding of haemosporidian life-history evolution and the origin of the human malaria parasites incomplete. Here we present the most comprehensive phylogenetic analysis of the malaria parasites conducted to date, using samples from a broad diversity of vertebrate hosts that includes numerous enigmatic and poorly known haemosporidian lineages in addition to genome-wide multi-locus sequence data. We find that if base composition differences were corrected for during phylogenetic analysis, we recovered a well-supported topology indicating that the evolutionary history of the malaria parasites was characterized by a complex series of transitions in life-history strategies and host usage. Notably we find that

Indexed as

base composition biasmalariaphylogenyPlasmodiumpolyphyly

Identifiers

PMID29892372
PMCPMC5990803

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.